Skin decontamination by low-temperature atmospheric pressure plasma jet and dielectric barrier discharge plasma
Skin decontamination by low-temperature atmospheric pressure plasma jet and dielectric barrier discharge plasma
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DOI：
10.1016/j.jhin.2012.02.012
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发表时间：
2012-07-01
影响因子：
6.9
通讯作者：
Juenger, M.
中科院分区：
文献类型：
--
作者：
Daeschlein, G.;Scholz, S.;Juenger, M.
背景：在过去的几年里，血浆医学已经成为医学科学的一个重要领域。目的：研究低温大气压等离子体射流（low temperature atmospheric pressure plasma jet，APPJ）和介质阻挡放电等离子体（dielectric barrier discharge plasma，DBD）两种冷等离子体源对人体指尖的体内去污能力。在用APPJ和DBD点处理3、15、30、60、90、120、150、180、210和240 s后，计算生理（PF）和人工（AF）污染的植物群（表皮葡萄球菌和藤黄微球菌）的对数减少因子（RF）。计数后测定细菌载量。耐受性（感觉异常，疼痛和热）进行了测量，使用一个数字rating scale.Findings：两个等离子体设备导致PF和AF的显着减少。PF的最大对数减少因子为1.3 DBD在210秒和0.8 APPJ在60秒。对于AF，90 s时DBD的最大对数减少因子为1.7，120 s时APPJ的最大对数减少因子为1.4。结论：APPJ和DBD都是非常有效的根除PF和AF从健康志愿者的指尖。未观察到耐血浆分离株。冷等离子体似乎具有皮肤消毒的潜力。出于手部卫生的目的，需要通过技术手段显著减少等离子体暴露时间。(C)2012年医疗感染学会。由爱思唯尔有限公司出版。保留所有权利。
Background: Over the past few years, plasma medicine has become an important field in medical science. Cold plasma has proven anti-inflammatory, antimicrobial and antineoplastic effects.Aim: To test the decontamination power of two cold plasma sources [low-temperature atmospheric pressure plasma jet (APPJ) and dielectric barrier discharge plasma (DBD)] in vivo on human fingertips.Methods: After 3, 15, 30, 60, 90, 120, 150, 180, 210 and 240 s of spot treatment with the APPJ and DBD, the log reduction factors (RFs) of physiological (PF) and artificially (AF) contaminated flora (Staphylococcus epidermidis and Micrococcus luteus) were calculated. The bacterial load was determined after counting. Tolerance (paresthesia, pain and heat) was measured using a numerical rating scale.Findings: Both plasma devices led to a significant reduction in PF and AF. The maximum log reduction factors for PF were 1.3 for the DBD at 210 s and 0.8 for the APPJ at 60 s. For AF, the maximum log reduction factors were 1.7 for the DBD at 90 s and 1.4 for the APPJ at 120 s. Treatment with both devices was well tolerated.Conclusion: Both the APPJ and DBD were highly effective in eradicating PF and AF from the fingertips of healthy volunteers. No plasma-resistant isolates were observed. Cold plasma appears to have potential for skin disinfection. For hand hygiene purposes, plasma exposure times would need to be reduced significantly by technical means. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.