External messengers and erythropoietin production.
External messengers and erythropoietin production.
复制标题
外部信使和促红细胞生成素的产生。
DOI：
10.1111/j.1749-6632.1989.tb22404.x
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发表时间：
1989
影响因子：
5.2
通讯作者：
Ueno,M
中科院分区：
文献类型：
--
作者：
Fisher,JW;Ueno,M
我们已经提出了一个模型，说明外部信使物质在低氧刺激肾脏产生促红细胞生成素中的作用。这些海龙类化合物可能协同作用，激活腺苷环化系统，促进促红细胞生成素的产生和/或分泌。在这个系统中产生的磷蛋白可以在促红细胞生成素的转录和翻译水平以及从细胞释放促红细胞生成素的水平上发挥作用。尽管二十烷基类和β2-肾上腺素能激动剂可能与轻度到中度缺氧有关，但随着缺氧程度的加重，腺苷似乎更有可能参与促红细胞生成素的产生。腺苷可能在缺氧中起着非常早期的作用，因为ATP的减少触发了促红细胞生成素的产生，在正常肾脏和某些肾脏和肝脏肿瘤中，在复氧和局部血流变化期间，腺苷的代谢物次黄嘌呤可能会产生过氧化氢。要完全阐明腺苷和氧自由基在调节肾脏促红细胞生成素生成中的作用，还需要在体内进行进一步的研究。
We have presented a model for the role of external messenger substances in hypoxic stimulation of kidney production of erythropoietin. These autacoids probably act in concert to activate the adenylate cyclase system to enhance production and/or secretion of erythropoietin. The phosphoproteins generated in this system could act at the level of transcription and translation of erythropoietin as well as at the level of release of erythropoietin from the cell. Even though eicosanoids and beta-2-adrenergic agonists may be involved in mild to moderate hypoxia, it seems more likely that adenosine is more involved in erythropoietin production with increasing severity of hypoxia. Adenosine may play a very early role in hypoxia following the decrease in ATP to trigger erythropoietin production, and hydrogen peroxide may be generated from hypoxanthine, a metabolite of adenosine, during reoxygenation and regional changes in blood flow in the normal kidney and perhaps in certain renal and hepatic tumors. Further work is necessary in vivo to completely clarify the role of adenosine and oxygen free radicals in regulating kidney production of erythropoietin.