Molecular markers in ALL: Clinical implications.
Molecular markers in ALL: Clinical implications.
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DOI：
10.1016/j.beha.2020.101193
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Mullighan CG
中科院分区：
文献类型：
--
作者：
Kimura S;Mullighan CG
急性淋巴细胞白血病（ALL）是最常见的儿童癌症，尽管治愈率最近有所提高，但仍然是儿童死亡的主要原因。在过去的十年中，大规模并行测序的发展使得大规模的 ALL 基因组分析研究成为可能，这不仅导致了 B 细胞前体 ALL (BCP-ALL) 和 T 细胞 ALL (T-ALL) 的新亚型的鉴定，而且还确定了针对许多亚型的脆弱性的潜在新治疗方法。其中几种方法已在临床前模型中得到验证，目前正在前瞻性临床试验中进行正式评估。在这篇综述中，我们概述了 BCP-ALL、T-ALL 和复发 ALL 基因组基础知识的最新进展，并讨论了它们的临床意义。
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and remains a main cause of death in children despite recent improvements in cure rates. In the past decade, development of massively parallel sequencing has enabled large scale genome profiling studies of ALL, which not only led to identification of new subtypes in both B-cell precursor ALL (BCP-ALL) and T-cell ALL (T-ALL), but has also identified potential new therapeutic approaches to target vulnerabilities of many subtypes. Several of these approaches have been validated in preclinical models and are now being formally evaluated in prospective clinical trials. In this review, we provide an overview of the recent advances in our knowledge of genomic bases of BCP-ALL, T-ALL, and relapsed ALL, and discuss their clinical implications.
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作者：
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通讯作者：
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