Multigenerational interstitial growth of biological tissues.
Multigenerational interstitial growth of biological tissues.
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DOI：
10.1007/s10237-010-0205-y
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发表时间：
2010-12
影响因子：
3.5
通讯作者：
Ricken, Tim
中科院分区：
文献类型：
--
作者：
Ateshian, Gerard A.;Ricken, Tim
这项研究制定了一个理论，为多代间质生长的生物组织，每一代有一个独特的参考配置确定在其沉积的时间。在该模型中，生长组织的固体基质由多个混合的多孔可渗透体组成，每个多孔可渗透体代表一代，所有这些多孔可渗透体都被约束为在当前配置中一起移动。每一代的参考配置都与主参考配置（通常是第一代的配置）有一对一的映射。这种映射是基于关于其沉积时的世代应力状态的本构假设而假定的。例如，即使下层组织处于加载构型，也可以假设新沉积的生成物处于无应力状态。由于生长或降解，每一代的质量含量可能随时间变化，从而改变组织的材料特性。这个框架的有限元实现是用来提供几个说明性的例子，包括细胞分裂，然后由矩阵营业额间质生长。
This study formulates a theory for multigenerational interstitial growth of biological tissues whereby each generation has a distinct reference configuration determined at the time of its deposition. In this model, the solid matrix of a growing tissue consists of a multiplicity of intermingled porous permeable bodies, each of which represents a generation, all of which are constrained to move together in the current configuration. Each generation’s reference configuration has a one-to-one mapping with the master reference configuration, which is typically that of the first generation. This mapping is postulated based on a constitutive assumption with regard to that generations’ state of stress at the time of its deposition. For example, the newly deposited generation may be assumed to be in a stress-free state, even though the underlying tissue is in a loaded configuration. The mass content of each generation may vary over time as a result of growth or degradation, thereby altering the material properties of the tissue. A finite element implementation of this framework is used to provide several illustrative examples, including interstitial growth by cell division followed by matrix turnover.
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影响因子：
3.5
作者：
Ateshian, Gerard A.
通讯作者：
Ateshian, Gerard A.
影响因子：
6.6
作者：
BOWEN, RM
通讯作者：
BOWEN, RM
影响因子：
2.6
作者：
Klisch, SM;Van Dyke, TJ
通讯作者：
Van Dyke, TJ
DOI：
10.1142/s0218202502001714
发表时间：
2002-03-01
影响因子：
3.5
作者：
Humphrey, JD;Rajagopal, KR
通讯作者：
Rajagopal, KR
DOI：
10.1016/s0020-7225(96)00119-x
发表时间：
1997-06-01
影响因子：
6.6
作者：
Huyghe, JM;Janssen, JD
通讯作者：
Janssen, JD