The role of early visual experience in the development of spatial‐frequency preference in the primary visual cortex
The role of early visual experience in the development of spatial‐frequency preference in the primary visual cortex
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DOI：
10.1113/jp281463
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发表时间：
2021-07
期刊：
影响因子：
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通讯作者：
Nana Nishio;K. Hayashi;A. Ishikawa;Y. Yoshimura
中科院分区：
文献类型：
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作者：
Nana Nishio;K. Hayashi;A. Ishikawa;Y. Yoshimura
初级视觉皮层的成熟功能依赖于出生后的视觉经验，而定向/方向偏好是在睁眼后建立的，独立于视觉经验。在本研究中，我们发现视觉经验是小鼠初级视觉皮层空间频率偏好正常发育的必要条件。我们发现，在兴奋性神经元和小白蛋白阳性的中间神经元中，年龄和经验依赖的最优SFs向更高频率的转移类似地发生。我们还发现，一些兴奋性和小白蛋白阳性神经元优先响应由非常高的SF和后向组成的视觉刺激，并且这种偏好比标准频率范围内的SF偏好建立在更早的发育阶段。这些结果表明，SF表征的发展需要早期的视觉经验，并揭示了视觉皮质功能背后的经验依赖的发展机制。
The mature functioning of the primary visual cortex depends on postnatal visual experience, while the orientation/direction preference is established just after eye‐opening, independently of visual experience. In this study, we find that visual experience is required for the normal development of spatial‐frequency (SF) preference in mouse primary visual cortex. We show that age‐ and experience‐dependent shifts in optimal SFs towards higher frequencies occurred similarly in excitatory neurons and parvalbumin‐positive interneurons. We also show that some excitatory and parvalbumin‐positive neurons preferentially responded to visual stimuli consisting of very high SFs and posterior directions, and that the preference was established at earlier developmental stages than the SF preference in the standard frequency range. These results suggest that early visual experience is required for the development of SF representation and shed light on the experience‐dependent developmental mechanisms underlying visual cortical functions.