Circulating proteomic profiles associated with endometriosis in adolescents and young adults.
Circulating proteomic profiles associated with endometriosis in adolescents and young adults.
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DOI：
10.1093/humrep/deac146
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发表时间：
2022-06
影响因子：
6.1
通讯作者：
Naoko Sasamoto;L. Ngo;A. Vitonis;S. Dillon;S. Missmer;T. Libermann;K. Terry
中科院分区：
文献类型：
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作者：
Naoko Sasamoto;L. Ngo;A. Vitonis;S. Dillon;S. Missmer;T. Libermann;K. Terry
研究问题在青少年和年轻人中诊断的子宫内膜异位症的系统分子特征是什么？与对照组相比，在子宫内膜异位症病例中观察到与血管生成和细胞迁移途径相关的蛋白质的显著富集和活化增加（P值1.2，揭示了与子宫内膜异位症相关的生物学途径中失调蛋白质的显著富集。与对照组相比，在子宫内膜异位症患者血浆中观察到与血管生成和细胞迁移相关的途径活化增加（P值< 2.4 × 10-8）。此外，当我们检查与病变颜色相关的蛋白质和途径时，血管化病变与免疫细胞迁移/活化和炎症相关途径的上调相关，而白色、蓝色/黑色和棕色病变与这些途径的下调相关。我们在独立数据集和机制研究中验证的结果有必要进一步了解这一常见但研究不足的患者人群的病理生理学特征。据我们所知，这是第一项全面检查患有和不患有子宫内膜异位症的主要是青少年和年轻成年女性的循环蛋白的研究。这项研究的结果提供了新的生物学见解，将建立对进一步的研究，以阐明子宫内膜异位症的病理生理学在疾病的早期过程中的轨迹。研究资金/竞争兴趣（S）这项研究得到了国防部（W81 XWH 1910318）和2017年波士顿子宫内膜异位症中心培训生奖的支持。J. Willard和Alice S.万豪基金会。不适用于：A.F. V S.A.M. KLT获得了万豪家庭基金会的资助。S.A.M.和K.L.T.支持NICHD（R 01 HD 94842）。S. A.M.担任AbbVie和Roche的顾问委员会成员;两者均与本研究无关。作者报告无利益冲突。试验注册编号N/A。
STUDY QUESTION What are the systemic molecular profiles of endometriosis diagnosed in adolescents and young adults? SUMMARY ANSWER Significant enrichment and increased activation of proteins related to angiogenesis and cell migration pathways were observed in endometriosis cases compared to controls (P-value 1.2, revealing significant enrichment of dysregulated proteins in biological pathways associated with endometriosis. Increased activation of pathways related to angiogenesis and cell migration was observed in plasma from endometriosis cases compared to controls (P-value < 2.4 × 10-8). Furthermore, when we examined proteins and pathways associated with lesion colors, vascularized lesions were associated with upregulation of pathways related to immune cell migration/activation and inflammation, whereas white, blue/black and brown lesions were associated with downregulation of these pathways. LIMITATIONS, REASONS FOR CAUTION Validation of our results in independent datasets and mechanistic studies are warranted to further our understanding of the pathophysiological characteristics of this common but understudied patient population. WIDER IMPLICATIONS OF THE FINDINGS To our knowledge, this was the first study to comprehensively examine circulating proteins in predominantly adolescents and young adult women with and without endometriosis. Results from this study provide novel biological insight that will build toward further research to elucidate endometriosis pathophysiology during the earlier course of the disease trajectory. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by the Department of Defense (W81XWH1910318) and the 2017 Boston Center for Endometriosis Trainee Award. Financial support for establishment of and data collection within the A2A cohort were provided by the J. Willard and Alice S. Marriott Foundation. N.S., A.F.V., S.A.M., K.L.T. have received funding from Marriott Family Foundation. S.A.M. and K.L.T. are supported by NICHD (R01 HD94842). S.A.M. serves as an advisory board member for AbbVie and Roche; neither are related to this study. The authors report no conflict of interest. TRIAL REGISTRATION NUMBER N/A.