DECREASED ADULT NEUROGENESIS IN HIBERNATING SYRIAN HAMSTER
DECREASED ADULT NEUROGENESIS IN HIBERNATING SYRIAN HAMSTER
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DOI：
10.1016/j.neuroscience.2016.07.016
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发表时间：
2016-10-01
期刊：
影响因子：
3.3
通讯作者：
Avila, Jesus
中科院分区：
文献类型：
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作者：
Leon-Espinosa, Gonzalo;Garcia, Esther;Avila, Jesus
成体神经干细胞在海马的齿状回和侧脑室的侧壁产生新的神经元。在这篇文章中，我们研究了发生在冬眠的叙利亚仓鼠（Mesocricetus auratus）的神经发生。使用各种标准的神经发生标志物和5-溴-2-脱氧尿苷（BrdU）的掺入，我们描述了一个优先减少新生神经元的增殖在室下区（SVZ）的冬眠仓鼠（麻木），而不是在海马。此外，我们证明，当在自然条件下触发唤醒时，在3-4天的麻木后，增殖能力恢复（即，不是人为的刺激）。此外，我们表明，tau 3R，一个tau亚型与三个微管结合域，是一个合适的标记，以研究神经发生在SVZ和颗粒下区（SGZ）的叙利亚仓鼠脑。(C)2016年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Generation of new neurons from adult neural stem cells occurs in the dentate gyrus (DG) of the hippocampus and the lateral walls of the lateral ventricles. In this article, we study the neurogenesis that takes place during the hibernation of the Syrian hamster (Mesocricetus auratus). Using a variety of standard neurogenesis markers and 5-bromo-2-deoxyuridine (BrdU) incorporation, we describe a preferential decrease in the proliferation of newborn neurons in the subventricular zone (SVZ) of the hibernating hamsters (torpor) rather than in the hippocampus. Furthermore, we demonstrate that the proliferative capacity is recovered after 3-4 days of torpor when arousal is triggered under natural conditions (i.e., not artificially provoked). In addition, we show that tau3R, a tau isoform with three microtubule-binding domains, is a suitable marker to study neurogenesis both in the SVZ and subgranular zone (SGZ) of the Syrian hamster brain. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.