FGF21 is an Akt-regulated myokine.
FGF21 is an Akt-regulated myokine.
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DOI：
10.1016/j.febslet.2008.10.021
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发表时间：
2008-11-12
期刊：
影响因子：
3.5
通讯作者：
Walsh, Kenneth
中科院分区：
文献类型：
--
作者：
Izumiya, Yasuhiro;Bina, Holly A.;Ouchi, Noriyuki;Akasaki, Yuichi;Kharitonenkov, Alexei;Walsh, Kenneth
FGF 21作为代谢调节剂发挥作用。据报道，FGF 21转录本在肝脏中大量表达，但对其他组织中FGF 21表达的调节知之甚少。在这项研究中，我们表明，FGF 21蛋白表达水平在骨骼肌和肝脏禁食小鼠相似。骨骼肌特异性Akt 1转基因小鼠腓肠肌中FGF 21转录和蛋白表达上调。Akt 1转基因激活也增加了FGF 21的血清浓度。在培养的骨骼肌细胞中，FGF 21的表达和分泌受胰岛素、Akt转导和LY 294002的调节。这些数据表明，骨骼肌是FGF 21的来源，其表达受PI 3-激酶/Akt 1信号通路依赖性机制调节。
FGF21 functions as a metabolic regulator. The FGF21 transcript is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21 expression in other tissues. In this study, we show that levels of FGF21 protein expression were similar in skeletal muscle and liver from fasted mice. FGF21 transcript and protein expression were upregulated in gastrocnemius muscle of skeletal muscle-specific Akt1 transgenic mice. Serum concentration of FGF21 was also increased by Akt1 transgene activation. In cultured skeletal muscle cells, FGF21 expression and secretion was regulated by insulin, Akt transduction and LY294002. These data indicate that skeletal muscle is a source of FGF21 and that its expression is regulated by a PI3-kinase/Akt1 signaling pathway-dependent mechanism.
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DOI：
10.1016/j.bbrc.2007.06.068
发表时间：
2007-08-24
影响因子：
3.1
作者：
Lundasen, Thomas;Hunt, Mary C.;Rudling, Mats
通讯作者：
Rudling, Mats
影响因子：
3
作者：
Grill, MA;Bales, MA;Antin, PB
通讯作者：
Antin, PB
影响因子：
29
作者：
Izumiya, Yasuhiro;Hopkins, Teresa;Walsh, Kenneth
通讯作者：
Walsh, Kenneth
影响因子：
5.5
作者：
Bolster, DR;Kubica, N;Jefferson, LS
通讯作者：
Jefferson, LS
影响因子：
29
作者：
Badman, Michael K.;Pissios, Pavlos;Maratos-Flier, Eleftheria
通讯作者：
Maratos-Flier, Eleftheria