Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia
Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia
复制标题
高度近视眼视神经乳头形态特征及脉络膜厚度
DOI：
10.1167/iovs.61.4.46
复制
发表时间：
2020-04-01
影响因子：
4.4
通讯作者：
Xu, Xun
中科院分区：
文献类型：
--
作者：
Hu, Guangyi;Chen, Qiuying;Xu, Xun
目的 本研究旨在探讨年轻健康高度近视眼的布鲁赫膜张开距离（BMOD）、边界长度（BL）、边界组织角（BTA）、垂直倾斜角和视乳头周围萎缩（PPA）的形态特征及其与脉络膜厚度（ChT）的关系。方法 纳入167例高度近视患者和172例非高度近视患者。所有受试者均按眼轴长度划分。 PPA 面积是根据眼底照片测量的。 BMOD、BL、BTA、垂直倾斜角、黄斑 ChT (mChT) 和视盘周围 ChT (pChT) 通过扫源光学相干断层扫描进行测量。结果 与非高度近视组相比，高度近视组PPA面积（P < 0.0001）和垂直倾斜角（P < 0.0001）较大，BMOD（P < 0.0001）和BL（P < 0.0001）较长，BTA（P < 0.0001）较小。 BMOD 每增加 1 µm，mChT 就会减少 35.80 µm； BTA 每降低 1°，mChT 就会降低 0.32 µm，pChT 就会降低 0.26 µm；在多元线性回归模型中未发现 PPA 面积与 ChT 之间存在关联。结论 对于年轻、健康的近视患者，随着眼球轴伸长，PPA 面积、BL、BMOD 和垂直倾斜角增加，但 BTA 减少。在该人群中，较长的 BMOD 与较低的 mChT 呈正相关，较小的 BTA 与较低的 mChT 和 pChT 呈正相关。
Purpose This study aimed to explore the morphological characteristics of Bruch's membrane opening distance (BMOD), border length (BL), border tissue angle (BTA), vertical tilt angle, and peripapillary atrophy (PPA), as well as their associations with choroidal thickness (ChT) in young healthy highly myopic eyes. Methods A total of 167 patients with high myopia and 172 individuals without high myopia were enrolled. All of the subjects were divided by axial length. The PPA area was measured on fundus photographs. BMOD, BL, BTA, vertical tilt angle, macular ChT (mChT), and peripapillary ChT (pChT) were measured on swept-source optical coherence tomography scans. Results The PPA area (P < 0.0001) and vertical tilt angle (P < 0.0001) were larger, BMOD (P < 0.0001) and BL (P < 0.0001) were longer, and BTA (P < 0.0001) was smaller in the high-myopia group compared with the group without high myopia. Every 1-µm increase in BMOD was associated with a 35.80-µm decrease in mChT; every 1° decrease in BTA was correlated with a 0.32-µm decrease in mChT and a 0.26-µm decrease in pChT; and no association was found between PPA area and ChT in the multivariate linear regression model. Conclusions PPA area, BL, BMOD, and vertical tilt angle increased, but BTA decreased with axial elongation of the globe in young, healthy patients with myopia. Longer BMOD was positively correlated with lower mChT, and smaller BTA was positively correlated with lower mChT and pChT in this population.