Modelling and simulation of the hydrodynamics and mixing profiles in the human proximal colon using Discrete Multiphysics
Modelling and simulation of the hydrodynamics and mixing profiles in the human proximal colon using Discrete Multiphysics
复制标题
DOI：
10.1016/j.compbiomed.2020.103819
复制
发表时间：
2020-06-01
影响因子：
7.7
通讯作者：
Alexiadis, A.
中科院分区：
文献类型：
--
作者：
Schutt, M.;Stamatopoulos, K.;Alexiadis, A.
结肠的近端部分提供了延长口服给药后的吸收窗口的机会。在这项工作中，我们使用计算机模拟来了解近端结肠中的流体动力学如何影响旨在靶向结肠的剂型的释放。为此，我们开发并比较了三种不同的模型：一个完全充满的结肠，一个部分充满的结肠和一个部分充满的结肠与气相存在（气-液模型）。液体的最高速度被发现在完全充满的模型，这也显示了最好的混合配置文件，定义的跟踪颗粒随时间的分布。在部分填充模型和气-液模型之间没有发现关于混合和速度分布的显著差异。在完全填充模型中发现未溶解片剂的最快通过时间。气-液模型中的液体速度沿结肠沿着略高于部分填充模型中的液体速度。灌装水平对现有的剪切力和剪切速率有影响，而剪切力和剪切速率是新药和新制剂开发的决定性因素。
The proximal part of the colon offers opportunities to prolong the absorption window following oral administration of a drug. In this work, we used computer simulations to understand how the hydrodynamics in the proximal colon might affect the release from dosage forms designed to target the colon. For this purpose, we developed and compared three different models: a completely-filled colon, a partially-filled colon and a partially-filled colon with a gaseous phase present (gas-liquid model).The highest velocities of the liquid were found in the completely-filled model, which also shows the best mixing profile, defined by the distribution of tracking particles over time. No significant differences with regard to the mixing and velocity profiles were found between the partially-filled model and the gas-liquid model. The fastest transit time of an undissolved tablet was found in the completely-filled model. The velocities of the liquid in the gas-liquid model are slightly higher along the colon than in the partially-filled model. The filling level has an impact on the exsisting shear forces and shear rates, which are decisive factors in the development of new drugs and formulations.