The plasticity of human Treg and Th17 cells and its role in autoimmunity.
The plasticity of human Treg and Th17 cells and its role in autoimmunity.
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DOI：
10.1016/j.smim.2013.10.009
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发表时间：
2013-11-15
影响因子：
7.8
通讯作者：
Hafler DA
中科院分区：
文献类型：
--
作者：
Kleinewietfeld M;Hafler DA
CD4+ T辅助细胞是适应性免疫系统的核心要素。它们保护生物体免受各种病原体的侵害，并能够与适应性和先天免疫系统的其他细胞结合启动和控制许多免疫反应。从幼稚细胞开始，CD4+ T细胞可以分化成具有专门功能的各种效应细胞群。这种亚群特异性分化取决于许多信号和刺激的强度。然而，最近的数据表明，分化的CD4+ T细胞亚群显示出高度的可塑性，并且它们的初始分化不是T细胞发育的终点。特别是，FoxP3+调节性T细胞（Treg）和Th17效应T细胞表现出高度的可塑性，其允许在免疫应答期间对各种生理情况的功能适应。然而，Treg和Th17细胞的可塑性也可能是自身免疫性疾病的关键因素。在这里，我们讨论了CD4+ T细胞可塑性的最新进展，重点是Treg和Th17细胞及其在人类自身免疫性疾病，特别是多发性硬化症（MS）中的作用。
CD4+ T helper cells are a central element of the adaptive immune system. They protect the organism against a wide range of pathogens and are able to initiate and control many immune reactions in combination with other cells of the adaptive and the innate immune system. Starting from a naïve cell, CD4+ T cells can differentiate into various effector cell populations with specialized function. This subset specific differentiation depends on numerous signals and the strength of stimulation. However, recent data have shown that differentiated CD4+ T cell subpopulations display a high grade of plasticity and that their initial differentiation is not an endpoint of T cell development. In particular, FoxP3+ regulatory T cells (Treg) and Th17 effector T cells demonstrate a high grade of plasticity, which allow a functional adaptation to various physiological situations during an immune response. However, the plasticity of Treg and Th17 cells might also be a critical factor for autoimmune disease. Here we discuss the recent developments in CD4+ T cell plasticity with a focus on Treg and Th17 cells and its role in human autoimmune disease, in particular multiple sclerosis (MS).
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Romagnani S
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
15.3
作者：
Apostolou, I;von Boehmer, H
通讯作者：
von Boehmer, H
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Honda K
影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten