Identification and characterization of a β 1-adrenergic receptor in the rat sertoli cell
Identification and characterization of a β
1-adrenergic receptor in the rat sertoli cell
复制标题
大鼠支持细胞中 β1-肾上腺素能受体的鉴定和表征
DOI：
10.1016/0303-7207(81)90043-5
复制
发表时间：
1981
影响因子：
4.1
通讯作者：
S. Strada
中科院分区：
文献类型：
--
作者：
J. Heindel;A. Steinberger;S. Strada
Theβ1-adrenergic receptor of rat Sertoli cells was characterized by measurement of the ability of adrenergic receptor agonists and antagonists to stimulate cAMP accumulation in Sertoli cells from 18-day-old rats. Epinephrine, norepinephrine and isoproterenol stimulate cAMP accumulation in Sertoli cells which is not additive with maximal doses of FSH and which is age-dependent. β-antagonists, alprenolol, hydroxybenzylpindolol or propranolol inhibit isoproterenol-induced cAMP accumulation while α-adrenergic antagonists have no effect.Dobutamine and soterenol stimulated cAMP accumulation to a greater extent than albuterol and metoproterenol. Finally, the stimulatory effects of isoproterenol and zinterol are both more sensitive to inhibition byβ1-antagonists than byβ2-antagonists. Taken together these data indicate the presence of aβ1-adrenergic receptor in Sertoli cells which is coupled to adenylate cyclase.
