Association of Polysensitization, Allergic Multimorbidity, and Allergy Severity: A Cross-Sectional Study of School Children
Association of Polysensitization, Allergic Multimorbidity, and Allergy Severity: A Cross-Sectional Study of School Children
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DOI：
10.1159/000453034
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发表时间：
2016-01-01
影响因子：
2.8
通讯作者：
Han, Man Yong
中科院分区：
文献类型：
--
作者：
Ha, Eun Kyo;Baek, Ji Hyeon;Han, Man Yong
背景：吸入性变应原致敏与过敏性疾病的共存有关，但这种关系的性质知之甚少。本研究的目的是阐明多敏性与变态反应性多发病和变态反应性疾病严重程度的关系。方法：本研究是对3，368名6-7岁韩国儿童的横断面分析。我们定义IgE介导的过敏性疾病的结构式问卷调查的基础上，分类的敏感性，18个空气过敏原的逻辑回归和沃德分层聚类方法。通过有序逻辑回归分析确定多致敏性（对2种或2种以上空气过敏原的阳性IgE反应）与过敏性多病（以下2种或2种以上过敏性疾病共存：哮喘、鼻炎、湿疹和结膜炎）和过敏性疾病严重程度的关系。结果如下：多敏反应发生率为13.6%（n = 458，95% CI 12.4-14.8），过敏性多敏反应发生率为23.5%（n = 790，95% CI 22.0-24.9）。对更多的空气过敏原致敏的儿童倾向于患更多的过敏性疾病（rho = 0.248，p < 0.001），尽管多致敏和多致敏之间的一致性很差（kappa = 0.11，p < 0.001）。儿童过敏的过敏原种类的数量增加了喘息发作的风险（1种过敏原：校正比值比[aOR] 2.22，4种或更多种过敏原：aOR 9.39），缺课（1种过敏原：aOR 1.96，3种过敏原：aOR 2.08）和鼻部症状的严重程度（1种过敏原：aOR 1.61，4种或更多种过敏原：aOR 4.38）。结论：多药致敏与多药耐药呈弱相关。然而，儿童致敏的过敏原的数量与IgE介导的症状的严重程度有关。(C)2017 S. Karger AG，巴塞尔
Background: Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multi morbidities and the severity of allergic diseases. Methods: This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method. The relationship of polysensitization (positive IgE responses against 2 or more aeroallergens classes) with allergic multimorbidities (coexistence of 2 or more of the following allergic diseases: asthma, rhinitis, eczema, and conjunctivitis) and severity of allergic diseases was determined by ordinal logistic regression analysis. Results: The rate of polysensitization was 13.6% (n = 458, 95% CI 12.4-14.8) and that of allergic multimorbidity was 23.5% (n = 790, 95% CI 22.0-24.9). Children sensitized to more aeroallergens tended to have more allergic diseases (rho = 0.248, p < 0.001), although the agreement between polysensitization and multimorbidity was poor (kappa = 0.11,p < 0.001). The number allergen classes to which a child was sensitized increased the risk of wheezing attacks (1 allergen: adjusted odds ratio [aOR] 2.22, 4 or more allergens: aOR 9.39), absence from school (1 allergen: aOR 1.96, 3 allergens: aOR 2.08), and severity of nasal symptoms (1 allergen: aOR 1.61, 4 or more allergens: aOR 4.38). Conclusion: Poly sensitization was weakly related to multimorbidity. However, the number of allergens to which a child is sensitized is related to the severity of IgE-mediated symptoms. (C) 2017 S. Karger AG, Basel