Functional connections of the rat medial cortex and basal forebrain: an in vivo intracellular study.
Functional connections of the rat medial cortex and basal forebrain: an in vivo intracellular study.
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大鼠内侧皮质和基底前脑的功能连接：体内细胞内研究。
DOI：
10.1016/0306-4522(91)90078-3
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发表时间：
1991
期刊：
影响因子：
3.3
通讯作者：
Finch,DM
中科院分区：
文献类型：
--
作者：
White,TD;Tan,AM;Finch,DM
通过细胞内记录和顺行示踪剂菜豆白细胞凝集素证实了大鼠内侧皮质和基底前脑之间的投射。这些区域之间的直接投影由逆向动作电位、短潜伏期（< 5 ms）顺向电位以及将菜豆白细胞凝集素离子导入后扣带皮层后基底前脑中标记的轴突末端表示。在反应性皮质神经元（66％）和基底前脑神经元（97％）中遇到高比例的逆向动作电位。基底前脑记录的逆向潜伏期（<1.0ms）显示出快速上升的投射；皮层神经元表现出快速和缓慢的下降投射（潜伏期为 0.32-3.7 毫秒）。在基底前脑中观察到的相对较少的突触电位（布罗卡的对角线带中没有）和稀疏的轴突末端标记表明，上升的投射可能是生理上更重要的，或者至少是最密集的通路。多突触前馈通路通过长潜伏期（< 20 ms）抑制性和兴奋性突触后电位提出，前者是更常见的反应。在皮质和基底前脑中均发现了候选抑制性神经元。这些细胞中可能的单突触（< 5 ms）抑制性突触后反应和逆向反应提供了候选抑制性神经元参与交互通路的证据。
Projections between the medial cortex and basal forebrain in the rat were demonstrated by intracellular recordings and the anterograde tracerPhaseolus vulgarisleucoagglutinin. Direct projections between these areas were indicated by antidromic action potentials, short latency ( < 5 ms) orthodromic potentials, and labeled axon terminals in the basal forebrain subsequent to iontophoresis ofPhaseolus vulgarisleucoagglutinin into posterior cingulate cortex. High proportions of antidromic action potentials were encountered in responsive cortical neurons (66%) and basal forebrain neurons (97%). Antidromic latencies recorded in the basal forebrain (< 1.0ms) revealed fast ascending projections; cortical neurons showed both fast and slow descending projections (latencies of 0.32–3.7 ms). Relatively few synaptic potentials (none in the diagonal band of Broca) and sparse labeling of axon terminals observed in the basal forebrain indicated that the ascending projections may be the more physiologically important or, at least, densest pathway. Polysynaptic feedforward pathways were suggested through long latency ( < 20 ms) inhibitory and excitatory postsynaptic potentials, the former being the more common response. Candidate inhibitory neurons were identified in both cortex and basal forebrain.Possible monosynaptic ( < 5 ms) inhibitory postsynaptic and antidromic responses in these cells provided evidence that candidate inhibitory neurons participate in the reciprocal pathways.