The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study
The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study
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DOI：
10.5507/bp.2016.044
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发表时间：
2016-01-01
影响因子：
0.9
通讯作者：
Tomasello, Giovanni
中科院分区：
文献类型：
--
作者：
Palumbo, Vincenzo Davide;Romeo, Marcello;Tomasello, Giovanni
瞄准肠道生态失调似乎是炎症性肠病的主要原因，益生菌似乎代表了对其发生的适当支持。事实上，益生菌混合物和抗炎药物是对抗炎症性肠病的武器。本研究评估了联合治疗（nnesalazine加唾液乳杆菌、嗜酸乳杆菌和双歧杆菌菌株BGN 4的益生菌混合物）对溃疡性结肠炎活性的长期（2年）作用。60名中重度溃疡性结肠炎患者入组：其中30名患者接受每日单次口服美沙拉秦1200 mg治疗; 30名患者接受每日单次口服nnesalazine 1200 mg和每日两次口服唾液乳杆菌、嗜酸乳杆菌和双歧杆菌菌株BGN 4的益生菌混合物治疗。采用改良马约疾病活动指数评价疗效。与对照组相比，所有接受联合治疗的患者均表现出更好的改善。特别是，益生菌的有益效果是明显的，即使经过两年的治疗。抗炎药和益生菌的长期治疗方式是可行的，并且可以成为轻至中度溃疡性结肠炎皮质类固醇的替代方案。
Aim. Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (nnesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacteriunn bifidus strain BGN4) on ulcerative colitis activity.Method. Sixty patients with moderate-to-severe ulcerative colitis were enrolled: 30 of them were treated with a single daily oral administration of mesalazine 1200 mg; 30 patients received a single daily oral administration of nnesalazine 1200 mg and a double daily administration of a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4. The treatment was carried out for two years and the clinical response evaluated according to the Modified Mayo Disease Activity Index.Results. All patients treated with combination therapy showed better improvement compared to the controls. In particular, the beneficial effects of probiotics were evident even after two years of treatment.Conclusions. A long-term treatment modality of anti-inflammatory drugs and probiotics is viable and could be an alternative to corticosteroids in mild-to moderate ulcerative colitis.