Chronic Neurologic Effects of Alcohol
Chronic Neurologic Effects of Alcohol
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DOI：
10.1016/j.cld.2018.09.010
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发表时间：
2019-02-01
影响因子：
5.1
通讯作者：
Jimenez-Shahed, Joohi
中科院分区：
文献类型：
--
作者：
Hammoud, Nadia;Jimenez-Shahed, Joohi
长期饮酒会导致中枢和外周神经系统的结构和功能发生隐匿性变化，最终产生不可逆转的、使人衰弱的影响。一旦确诊，营养补充和戒酒措施对于防止神经系统进一步受损至关重要。慢性酗酒中神经元损伤的可能机制包括酒精的直接毒性作用以及间接作用，间接作用包括肝功能障碍、营养缺乏和神经炎症所导致的影响。临床表现包括小脑性共济失调、周围神经病变和韦尼克 - 科尔萨科夫脑病。对病理生理机制的持续探索可能会促使发现能够预防永久性神经损伤的早期干预措施。
Chronic alcohol use induces silent changes in the structure and function of the central and peripheral nervous systems that eventually result in irreversible, debilitating repercussions. Once identified, nutritional supplementation and cessation measures are critical in preventing further neurologic damage. The proposed mechanisms of neuronal injury in chronic alcohol abuse include direct toxic effects of alcohol and indirect effects, including those resulting from hepatic dysfunction, nutritional deficiencies, and neuroinflammation. Clinical manifestations include cerebellar ataxia, peripheral neuropathy and Wernicke-Korsakoff encephalopathy. Continued exploration of the pathophysiologic mechanisms may lead to the discovery of early interventions that can prevent permanent neurologic injury.