EFFECTS OF LESIONS TO ASCENDING NORADRENERGIC NEURONS ON PERFORMANCE OF A 5-CHOICE SERIAL REACTION TASK IN RATS - IMPLICATIONS FOR THEORIES OF DORSAL NORADRENERGIC BUNDLE FUNCTION BASED ON SELECTIVE ATTENTION AND AROUSAL
EFFECTS OF LESIONS TO ASCENDING NORADRENERGIC NEURONS ON PERFORMANCE OF A 5-CHOICE SERIAL REACTION TASK IN RATS - IMPLICATIONS FOR THEORIES OF DORSAL NORADRENERGIC BUNDLE FUNCTION BASED ON SELECTIVE ATTENTION AND AROUSAL
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DOI：
10.1016/0166-4328(83)90138-9
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发表时间：
1983-01-01
影响因子：
2.7
通讯作者：
EVERITT, BJ
中科院分区：
文献类型：
--
作者：
CARLI, M;ROBBINS, TW;EVERITT, BJ
五项实验研究了蓝斑中发生的背侧去甲肾上腺素束（DNAB）破坏对亮度、空间视觉辨别力和选择性注意力的影响。使用了伦纳德针对人类受试者的 5 个选择的串行缩减任务的类似物。训练饥饿的大鼠检测在 5 个位置中的 1 个随机出现的短暂（0.5 秒）闪光，固定间隔为 5 秒，由大鼠调节。正确的反应会得到食物的奖励，错误的反应会受到暂停（黑暗+延迟）的惩罚。经过高精度训练（80%，遗漏误差 < 20%）后，大鼠接受双侧背束轨迹注射 6-OHDA [羟基多巴胺] (4 μg/2 μl) 或注射媒介物（0.9% 盐水中的 0.1% 抗坏血酸）。 6-OHDA 损伤足以使皮质 NA [去甲肾上腺素] 减少 84%。空间辨别和亮度（由刺激亮度分级降低产生）辨别的表现不受 DNAB 损伤的影响。当刺激以更快、不可预测的速度呈现时，DNAB 损伤会导致准确性显着下降，遗漏率也会增加。虽然强烈的白噪声在与视觉辨别同时出现时未能产生差异性损伤，但当噪声在视觉刺激开始之前出现但不重叠时，DNAB 损伤会显着损害准确性。 DNAB 损伤后发现的这种表现缺陷模式的含义是根据皮质 NA 消耗对选择性注意和唤醒机制的破坏性影响进行讨论的。
Five experiments examined the effects of destruction of the dorsal noradrenergic bundle (DNAB), arising in the locus coeruleus, both on brightness and spatial visual discrimination and selective attention. An analogue of Leonard''s 5-choice serial reduction task for human subjects was used. Hungry rats were trained to detect brief (0.5 s) flashes of light presented randomly in 1 of 5 locations with a fixed intertrial interval of 5 s, paced by the rat. Correct responses were rewarded with food and incorrect responses punished by time-out (darkness + delay). Following training to high levels of accuracy (80%, with < 20% errors of omission), rats received either 6-OHDA [hydroxydopamine] (4 .mu.g/2 .mu.l) injected bilaterally into the trajectory of the dorsal bundle or injection of vehicle (0.1% ascorbic acid in 0.9% saline). The 6-OHDA lesion was sufficient to reduce cortical NA [noradrenaline] by 84%. Performance on both the spatial discrimination and brightness (produced by graded reductions in the brightness of the stimuli) discrimination was unaffected by DNAB lesions. The DNAB lesion produced significant decreases in accuracy and increases in omissions when the stimuli were presented at faster, unpredictable rates. Although intense white noise failed to produce differential impairments when presented simultaneously with the visual discriminanda, the DNAB lesion significantly impaired accuracy when the noise was presented immediately prior to, but not overlapping, the onset of the visual stimuli. The implications of this pattern of deficits in performance found following DNAB lesions is discussed in terms of disruptive effects of cortical NA depletion upon mechanisms of selective attention and arousal.