Characterization and Development of Universal Ventricular Assist Device: Computational Fluid Dynamics Analysis of Advanced Design.
Characterization and Development of Universal Ventricular Assist Device: Computational Fluid Dynamics Analysis of Advanced Design.
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DOI：
10.1097/mat.0000000000001607
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发表时间：
2022-08-01
期刊：
影响因子：
4.2
通讯作者：
Karimov, Jamshid H.
中科院分区：
文献类型：
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作者：
Goodin, Mark S.;Showalter, Michael S.;Horvath, David J.;Kuban, Barry D.;Flick, Christine R.;Polakowski, Anthony R.;Fukamachi, Kiyotaka;Karimov, Jamshid H.
关键词：
我们正在开发一种通用的，先进的心室辅助装置（AVAD），具有自动压力调节，适用于左心室和右心室支持。这项计算流体动力学（CFD）研究的主要目标是分析AVAD在各种工作条件下的双心室性能。通过左心室辅助装置（LVAD）和右心室辅助装置（RVAD）的体外水力性能测量，建立并验证了AVAD CFD模型。在整个泵中放置静压水龙头，用于验证CFD结果。然后利用CFD模型评估了转子轴向位置变化时水力性能的变化，并确定了可能的设计改进。在转子转速为2300 ~ 3600转/分钟，流量为2.0 ~ 8.0升/分钟的情况下，对液压性能进行了模拟和测量。cfd预测的液压压力上升与体外测量数据一致，在2300 rpm时在6.5%以内，在更高转子转速时在3.5%以内。CFD成功地预测了壁面静压，与实验值匹配在7%以内。在泵作为LVAD和RVAD的运行过程中，泵的流场具有高度的相似性和周向均匀性。二次叶轮轴向间隙减小，峰值停留时间减少10%，二次叶轮静压降低。这些较低的静压表明减少了向上转子力从二次叶轮和期望增加压力敏感性的泵。CFD分析支持了AVAD作为LVAD或RVAD在多种工况下使用的可行性。CFD结果表明，在预期的流量/速度范围内，泵在提供所需的周向流动相似性方面具有可操作性，并且AVAD的自动压力调节功能也具有预期的功能。
We are developing a universal, advanced ventricular assist device (AVAD) with automatic pressure regulation suitable for both left and right ventricular support. The primary goal of this computational fluid dynamics (CFD) study was to analyze the biventricular performance of the AVAD across its wide range of operating conditions. An AVAD CFD model was created and validated using in vitro hydraulic performance measurements taken over conditions spanning both left ventricular assist device (LVAD) and right ventricular assist device (RVAD) operation. Static pressure taps, placed throughout the pump, were used to validate the CFD results. The CFD model was then used to assess the change in hydraulic performance with varying rotor axial position and identify potential design improvements. The hydraulic performance was simulated and measured at rotor speeds from 2,300 to 3,600 revolutions/min and flow rates from 2.0 to 8.0 liters/min. The CFD-predicted hydraulic pressure rise agreed well with the in vitro measured data, within 6.5% at 2300 rpm and within 3.5% for the higher rotor speeds. The CFD successfully predicted wall static pressures, matching experimental values within 7%. High degree of similarity and circumferential uniformity in the pump’s flow fields were observed over the pump operation as LVAD and RVAD. A secondary impeller axial clearance reduction resulted in a 10% decrease in peak flow residence time and lower static pressures on the secondary impeller. These lower static pressures suggest a reduction in the upwards rotor forces from the secondary impeller and a desired increase the pressure sensitivity of the pump. The CFD analyses supported the feasibility of the proposed AVAD’s use as LVAD or a RVAD, over a wide range of operating conditions. The CFD results demonstrated the operability of pump in providing the desired circumferential flow similarity over the intended range of flow/speed conditions and the intended functionality of the AVAD’s automated pressure regulation.