INTERACTIONS OF MONOAMINE OXIDASE INHIBITORS AND RESERPINE - AN EEG GROSS BEHAVIORAL AND BIOCHEMICAL ANALYSIS
INTERACTIONS OF MONOAMINE OXIDASE INHIBITORS AND RESERPINE - AN EEG GROSS BEHAVIORAL AND BIOCHEMICAL ANALYSIS
复制标题
DOI：
10.1007/bf00401345
复制
发表时间：
1968-01-01
期刊：
影响因子：
--
通讯作者：
HIMWICH, HE
中科院分区：
文献类型：
--
作者：
BUENO, JR;PSCHEIDT, GR;HIMWICH, HE
本文研究了利血平与单胺氧合酶抑制剂烟酰胺和水胺酮在兔体内的相互作用。脑电记录来自具有急性和长期植入电极的动物。对自由活动兔进行了大体行为观察，并测定了脑胺中去甲肾上腺素和5-羟色胺的浓度。重点是在长达13天的时间内观察效果。单独给予水胺硫脲或烟酰胺的兔表现出在对照组动物中罕见的现象，即部分激活，这是一种脑电模式，在皮质中保持高幅度的慢波，而在皮质下结构中出现快速活动。在联合应用烟酰胺和利普林的兔身上也观察到了这种效果。通过适当的给药方案，给用单胺氧合酶抑制剂预处理的动物服用利普林，可以在几天的时间内保持较长时间的清醒或脑电活动。脑胺的绝对浓度与观察到的脑电效应几乎没有关系，5-羟色胺/去甲肾上腺素的比率增加与脑电激活和行为兴奋的迹象有关。
The interactions of reserplne and the monoamlne oxldase inhibitors, nialamide and isocarboxazld, were studied, in rabbits. EEG recordings were made from animals with acute and chronically implanted electrodes. Gross behavioral observations were made in freely moving rabbits and brain amine concentrations of norepinephrine and serotonin [5-hydroxytryptamine] were also determined. Emphasis was placed on observing effects over periods of time ranging up to 13 days. Rabbits given isocarboxazld or nialamide alone exhibit a phenomenon rarely seen in the control animals, namely partial activation, an eeg pattern in which slow waves of high amplitude are maintained in the cortex while fast activity appears in subcortical structures. This effect was also observed in rabbits treated with nialamide and reserplne in combination. By appropriate dosage schedules in which reserplne was administered to animals pre-treated with monoamlne oxldase inhibitors it was possible to maintain extended periods of frank arousal or eeg activation over a period of several days. The absolute concentrations of brain amines bore little or no relationship to the eeg effects observed, increased ratios of serotonin to norepinephrine were observed in conjunction with eeg activation and signs of behavioral excitement.