Mechanical characterization of fish oil microcapsules by a micromanipulation technique
Mechanical characterization of fish oil microcapsules by a micromanipulation technique
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DOI：
10.1016/j.lwt.2021.111194
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Fanqianhui Yu;C. Xue;Zhibing Zhang
中科院分区：
文献类型：
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作者：
Fanqianhui Yu;C. Xue;Zhibing Zhang
本文旨在研究不同食品级配方和工艺条件下制备的鱼油微胶囊的力学性能，这对于进一步压片时保持其机械完整性是至关重要的，从而开发出最终的片剂。使用明胶和阿拉伯胶或麦芽糊精的组合作为墙体材料。采用喷雾干燥、复合凝聚和双重包埋(凝聚后喷雾包衣)的方法制备了不同种类的鱼油微胶囊。考察了微胶囊的基本物理性能和力学性能。微胶囊的力学表征结果表明，单个微胶囊的平均破碎力在0.44±0.11~1.73±0.27 MN之间，并且随着粒径的增大有增大的趋势。通过用Hertz模型对实验力-位移数据进行拟合，确定了微胶囊的杨氏模数。由明胶和阿拉伯树胶凝聚，然后用明胶和麦芽糊精的混合物喷涂层制备的微胶囊，根据计算的名义破裂应力和杨氏模数分别计算出最强和最硬的微胶囊。这些发现可以为选择最理想的配方和工艺条件以生产具有良好阻隔性能的工业应用的坚固微胶囊提供指导。
This paper aims to study the mechanical properties of fish oil microcapsules made of different food-grade formulations and processing conditions, which is crucial to maintaining their mechanical integrity in further compaction for developing the final dosage form of tablet. The combination of gelatin and gum Arabic or maltodextrin were use as wall materials. Spray drying, complex coacervation, and double encapsulation (coacervation followed by spray coating) were used to prepare different fish oil microcapsules. Both fundamental physical properties and mechanical properties of microcapsules were investigated. The mechanical characterization results were obtained using a micromanipulation technique and revealed that the mean rupture forces of individual microcapsules ranged from 0.44 ± 0.11 to 1.73 ± 0.27 mN and tended to increase with increasing particle size. The Young's modulus of microcapsules was determined by fitting the experimental force versus displacement data with the Hertz model. The microcapsules prepared by coacervation of gelatin and gum Arabic followed by spray coating with a mixture of gelation and maltodextrin were the strongest and stiffest based on the calculated nominal rupture stress and Young's modulus respectively. These findings can provide guidance on choosing the most desirable formulation and processing conditions to produce strong microcapsules with desirable barrier properties for industrial applications.