Sequential histologic changes during gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI and resistant BUF rats.
Sequential histologic changes during gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI and resistant BUF rats.
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N-甲基-N-硝基-N-亚硝基胍在易感 ACI 和耐药 BUF 大鼠中诱导胃癌发生过程中的连续组织学变化。
DOI：
10.1093/jnci/77.3.747
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
T. Sugimura
中科院分区：
文献类型：
--
作者：
H. Ohgaki;K. Kusama;H. Hasegawa;S. Sato;S. Takayama;T. Sugimura
本文研究了N-甲基-N '-硝基-N-亚硝基胍（MNNG; CAS：70-25-7）诱发ACI敏感和BUF抗性品系大鼠癌变过程中胃的组织学变化。大鼠在饮用水中给予浓度为83微克/毫升的MNNG，持续32周，然后是自来水，并在第1周至第57周期间依次处死。在ACI大鼠中，在MNNG给药期间，在幽门区依次观察到糜烂、再生性变化、局灶性和轻度非典型变化以及弥漫性和重度非典型变化，其中在MNNG治疗停止后观察到腺癌。在BUF大鼠中，MNNG引起的主要组织学变化是幽门腺的糜烂和糜烂边缘的腺部增生。MNNG治疗停止后，幽门腺的增生消退，随后这些腺体萎缩。结果提示，急性脑梗死和慢性心力衰竭大鼠胃粘膜对MNNG的反应存在质的差异。
Sequential histologic changes of the stomach during carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG; CAS: 70-25-7) were studied in susceptible ACI and resistant BUF strain rats. Rats were given MNNG at a concentration of 83 micrograms/ml in their drinking water for 32 weeks and then tap water and were sacrificed sequentially between weeks 1 and 57. In ACI rats, erosions, regenerative changes, focal and slightly atypical changes, and diffuse and severe atypical changes were observed sequentially in the pyloric region during the period of MNNG administration, where adenocarcinomas were observed after the cessation of MNNG treatment. In BUF rats, the main histologic changes induced by MNNG were erosions and hyperplasia of the glandular portion of pyloric glands at the margin of erosions. After the cessation of MNNG treatment, the hyperplasia of the pyloric glands subsided and was followed by atrophy of these glands. The results suggested that the responses of the gastric mucosa to MNNG in ACI and BUF rats were qualitatively different.