Expression of the mouse hepatitis virus receptor by central nervous system microglia
Expression of the mouse hepatitis virus receptor by central nervous system microglia
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DOI：
10.1128/jvi.78.14.7828-7832.2004
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发表时间：
2004-07-01
影响因子：
5.4
通讯作者：
Stohlman, SA
中科院分区：
文献类型：
--
作者：
Ramakrishna, C;Bergmann, CC;Stohlman, SA
中枢神经系统（CNS）内小鼠肝炎病毒受体的检测一直是难以捉摸的。小胶质细胞上的受体表达在急性感染期间减少，并在免疫介导的病毒控制后恢复。受体下调是独立的中性粒细胞，NK细胞，γ干扰素，或穿孔素。感染缺乏明显炎性细胞的小鼠，发现CD4（+）T细胞是影响小胶质细胞受体表达的主要细胞类型。除了证明CNS驻留细胞上的受体表达外，这些数据还表明，小胶质细胞上的瞬时受体下调有助于通过辅助病毒感染其他胶质细胞类型来建立CNS中的持久性。
Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control. Receptor down regulation was independent of neutrophils, NK cells, gamma interferon, or perforin. Infection of mice devoid of distinct inflammatory cells revealed CD4(+) T cells as the major cell type influencing receptor expression by microglia. In addition to demonstrating receptor expression on CNS resident cells, these data suggest that transient receptor down regulation on microglia aids in establishing persistence in the CNS by assisting virus infection of other glial cell types.