ALTERED GLUCOSE-TOLERANCE IN RATS EXPOSED TO MATERNAL LOW-PROTEIN DIETS IN-UTERO
ALTERED GLUCOSE-TOLERANCE IN RATS EXPOSED TO MATERNAL LOW-PROTEIN DIETS IN-UTERO
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DOI：
10.1016/0300-9629(94)90124-4
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发表时间：
1994-10-01
期刊：
影响因子：
--
通讯作者：
JACKSON, AA
中科院分区：
文献类型：
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作者：
LANGLEY, SC;BROWNE, RF;JACKSON, AA
在胎仔暴露于含18%、12%、9%或6%蛋白质的母体饮食后，在四组大鼠中评价了对静脉内葡萄糖负荷的反应。这些动物的营养差异仅在于产前经历。6%蛋白质暴露组的动物在所有年龄段均表现出较低的体重，而9%和12%蛋白质暴露大鼠的体重与对照组无差异。在9周龄时，2g/kg体重的静脉内葡萄糖负荷在60分钟内被18%蛋白质暴露的大鼠、对照大鼠和12%蛋白质暴露的大鼠清除。这些动物的峰值血糖浓度分别为27.2和27.1 mM。在子宫内暴露于9%蛋白质的大鼠也在60分钟内清除了葡萄糖负荷，但血糖峰值浓度较低（24.4 mM），葡萄糖耐量曲线下面积比对照组低28%。6%蛋白暴露组大鼠在40分钟内清除了葡萄糖负荷，血糖峰值水平仅为22.1 mM。葡萄糖耐量曲线下面积相对于对照组减少了40%。当在44周龄的动物中重复葡萄糖耐量试验时，未观察到峰值葡萄糖浓度、曲线下面积或葡萄糖清除率的差异。因此，在子宫内暴露于母体低蛋白饮食的大鼠已被证明可以通过一种尚未明确的机制改变成年早期的葡萄糖耐量。
The response to an intravenous glucose load was evaluated in four groups of rats following fetal exposure to maternal diets containing 18, 12, 9 or 6% protein. The animals differed nutritionally only in terms of this prenatal experience. Animals in the 6% protein exposed group exhibited lower body weights at all ages, whilst the body weights of 9 and 12% protein exposed rats did not differ from the control group. At 9 weeks of age, a 2 g/kg body weight intravenous glucose load was cleared in 60 min by 18% protein exposed, control rats and 12% protein exposed rats. Peak blood glucose concentrations in these animals were 27.2 and 27.1 mM, respectively. Rats exposed to 9% protein in utero also cleared the glucose load in 60 min, but peak blood glucose concentrations were lower (24.4 mM), and the area under the glucose tolerance curve was 28% lower than in controls. Rats in the 6% protein exposed group cleared the glucose load in 40 min and peak blood glucose levels were only 22.1 mM. The area under the glucose tolerance curve was reduced by 40% relative to controls. When the glucose tolerance test was repeated in animals aged 44 weeks, no differences in peak glucose concentrations, area under the curve or rates of glucose clearance were observed. In utero exposure of rats to maternal low protein diets has been shown, therefore, to alter glucose tolerance in young adulthood through an, as yet, undefined mechanism.