Early chordate origins of the vertebrate second heart field.
Early chordate origins of the vertebrate second heart field.
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DOI：
10.1126/science.1190181
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发表时间：
2010-07-30
期刊：
影响因子：
--
通讯作者：
Christiaen L
中科院分区：
文献类型：
--
作者：
Stolfi A;Gainous TB;Young JJ;Mori A;Levine M;Christiaen L
脊椎动物的心脏是由不同的胚胎领域形成的，包括第一和第二心脏领域。第二心野（SHF）产生右心室和流出道，但其进化起源尚不清楚。我们发现，简单的脊索动物玻璃海鞘的心脏祖细胞也产生心房虹吸肌（ASMs）的前体。这些前体表达Islet和Tbx 1/10，唤起产生脊椎动物下颌肌肉和SHF的内脏中胚层。有证据表明，转录因子COE是ASM命运的关键决定因素。我们认为被囊动物和脊椎动物的最后共同祖先具有多能心咽肌前体，它们的重新分配可能有助于SHF的出现。
The vertebrate heart is formed from diverse embryonic territories, including the first and second heart fields. The second heart field (SHF) gives rise to the right ventricle and outflow tract, yet its evolutionary origins are unclear. We found that heart progenitor cells of the simple chordate Ciona intestinalis also generate precursors of the atrial siphon muscles (ASMs). These precursors express Islet and Tbx1/10, evocative of the splanchnic mesoderm that produces the lower jaw muscles and SHF of vertebrates. Evidence is presented that the transcription factor COE is a critical determinant of ASM fate. We propose that the last common ancestor of tunicates and vertebrates possessed multipotent cardiopharyngeal muscle precursors, and that their reallocation might have contributed to the emergence of the SHF.