Calcium homeostasis in ageing: Studies on the calcium binding protein calbindin D28K
Calcium homeostasis in ageing: Studies on the calcium binding protein calbindin D28K
复制标题
衰老过程中的钙稳态：钙结合蛋白钙结合蛋白 D28K 的研究
DOI：
10.1007/bf01273323
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发表时间：
2005
影响因子：
3.3
通讯作者：
P. Emson
中科院分区：
文献类型：
--
作者：
G. Lally;R. Faull;H. Waldvogel;S. Ferrari;P. Emson
钙结合蛋白D28K是一种神经元钙结合蛋白，可作为神经元钙的缓冲剂。有证据表明，钙稳态的紊乱在神经退行性变中是重要的，可能通过钙结合蛋白D28K的变化。在阿尔茨海默病和年龄匹配的对照中比较钙结合蛋白D28K的免疫反应性。阿尔茨海默病组织中钙结合蛋白D28K阳性神经元的大小和数量减少。树突状树也有收缩。继续的工作使用转基因小鼠检查钙结合蛋白D28K的功能。
SummaryCalbindin D28K is a neuronal calcium binding protein which may act as a buffer of neuronal calcium. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration, possibly via changes in calbindin D28K. Immunoreactivity of calbindin D28K is compared in Alzheimer's disease and age-matched controls. The size and number of calbindin D28K positive neurons in Alzheimer's disease tissue is reduced. There is also shrinkage of the dendritic tree. Continuing work examines the function of calbindin D28K using transgenic mice.