Functional organization and population dynamics in the mouse primary auditory cortex
Functional organization and population dynamics in the mouse primary auditory cortex
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DOI：
10.1038/nn.2484
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发表时间：
2010-03-01
影响因子：
25
通讯作者：
Mizrahi, Adi
中科院分区：
文献类型：
--
作者：
Rothschild, Gideon;Nelken, Israel;Mizrahi, Adi
听觉刺激的皮层处理涉及大量具有不同个体反应特征的神经元。然而，听觉皮层中局部人群的功能组织和动态在很大程度上仍然未知。利用在体双光子钙离子成像技术，我们研究了小鼠初级听皮层（A1）第2/3层神经元对纯音的反应曲线和网络动力学。我们发现，当地人口在A1是高度异质性的大规模tonotopic组织。尽管存在空间异质性，但神经元共同响应的趋势（以噪声相关性衡量）平均较高。这种功能组织和高水平的噪声相关性与部分重叠的皮层子网络的存在是一致的。我们的研究结果可以解释有序的大规模组织和局部异质性之间的明显差异。
Cortical processing of auditory stimuli involves large populations of neurons with distinct individual response profiles. However, the functional organization and dynamics of local populations in the auditory cortex have remained largely unknown. Using in vivo two-photon calcium imaging, we examined the response profiles and network dynamics of layer 2/3 neurons in the primary auditory cortex (A1) of mice in response to pure tones. We found that local populations in A1 were highly heterogeneous in the large-scale tonotopic organization. Despite the spatial heterogeneity, the tendency of neurons to respond together ( measured as noise correlation) was high on average. This functional organization and high levels of noise correlations are consistent with the existence of partially overlapping cortical subnetworks. Our findings may account for apparent discrepancies between ordered large-scale organization and local heterogeneity.