Antiinflammatory effects of endotoxin. Inhibition of rabbit polymorphonuclear leukocyte responses to complement (C5)-derived peptides in vivo and in vitro.
Antiinflammatory effects of endotoxin. Inhibition of rabbit polymorphonuclear leukocyte responses to complement (C5)-derived peptides in vivo and in vitro.
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内毒素的抗炎作用。
DOI：
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发表时间：
1983
影响因子：
6
通讯作者：
I. Goldstein
中科院分区：
文献类型：
--
作者：
J. Rosenbaum;K. Hartiala;R. Webster;E. Howes;I. Goldstein
尽管内毒素（细菌脂多糖）能够引起多种炎症反应，但矛盾的是，据报道内毒素是可抑制的。作者发现，在激发前24小时单次静脉注射大肠杆菌内毒素，几乎完全抑制了由逆转的被动Arthus反应诱导的兔皮肤中的血管通透性变化和多形核白细胞渗出。而静脉注射内毒素也引起适度的抑制血管通透性的变化诱导兔皮肤的合成肽N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸（FMLP），渗出的多形核白细胞不受影响。在体外，给予单次注射剂量的内毒素的家兔的多形性白细胞对补体（C5）衍生肽的趋化和脱粒反应显着降低。然而，这些细胞对FMLP的反应是正常的。这些数据表明，选择性抑制多形核白细胞对C5衍生肽的反应，部分原因是内毒素的抑制作用。
Although capable of provoking a variety of inflammatory effects, endotoxin (bacterial lipopolysaccharide) paradoxically has been reported to be antiinflammatory. The authors have found that single intravenous injections of Escherichia coli endotoxin, 24 hours before challenge, inhibit almost completely the vascular permeability changes and exudation of polymorphonuclear leukocytes induced in rabbit skin by reversed passive Arthus reactions. Whereas intravenous injections of endotoxin also caused modest inhibition of the vascular permeability changes induced in rabbit skin by the synthetic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP), exudation of polymorphonuclear leukocytes was unaffected. Polymorphonuclear leukocytes from rabbits given single injected doses of endotoxin exhibited markedly diminished chemotactic and degranulation responses to complement (C5)-derived peptides in vitro. Responses of these cells to FMLP, however, were normal. These data suggest that selective suppression of polymorphonuclear leukocyte responses to C5-derived peptides accounts, in part, for the antiinflammatory effects of endotoxin.
LPS 对敏感和耐药小鼠品系的不同抗炎作用。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Verghese,MW;Snyderman,R
通讯作者：
Snyderman,R
花生四烯酸脂氧合酶产物对人中性粒细胞趋化失活的刺激特异性。
DOI：
10.1016/0090-6980(81)90042-3
发表时间：
1981
期刊：
Prostaglandins
影响因子：
--
作者：
Goetzl,EJ;Boeynaems,JM;Oates,JA;Hubbard,WC
通讯作者：
Hubbard,WC