Acylglycerol Kinase-Targeted Therapies in Oncology.
Acylglycerol Kinase-Targeted Therapies in Oncology.
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DOI：
10.3389/fcell.2021.659158
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发表时间：
2021
影响因子：
5.5
通讯作者：
Zheng X
中科院分区：
文献类型：
--
作者：
Chu B;Hong Z;Zheng X
酰基甘油激酶（Acylglycerol kinase，AGK）是近年来发现的一种线粒体脂质激酶，其基因突变是引起皮肤病综合征的根本原因。AGK不仅参与脂质代谢的稳定，而且与线粒体蛋白转运、糖酵解、血小板生成等密切相关。有证据表明，AGK在肿瘤的发生、发展中起着重要作用。具体而言，AGK已被鉴定为参与调节肿瘤细胞生长、侵袭、转移和耐药性的癌基因。AGK的多功能性及其在不同类型的癌细胞和正常细胞中的独特作用极大地激发了我们的兴趣。我们相信AGK是一个很有前途的肿瘤治疗靶点。本文综述了AGK的主要研究进展，包括其生理/致病机制的发现，并为评估AGK作为人类疾病特别是肿瘤治疗靶点的可行性提供参考。
Acylglycerol kinase (AGK) is a recently discovered mitochondrial lipid kinase, and mutation of its gene is the fundamental cause of Sengers syndrome. AGK is not only involved in the stability of lipid metabolism but also closely related to mitochondrial protein transport, glycolysis, and thrombocytopoiesis. Evidence indicates that AGK is an important factor in the occurrence and development of tumors. Specifically, AGK has been identified as an oncogene that partakes in the regulation of tumor cell growth, invasion, metastasis, and drug resistance. The versatility of AGK and its unique role in different types of cancerous and normal cells greatly piqued our interest. We believe that AGK is a promising target for cancer therapy. Therefore, this review summarizes the main research advances concerning AGK, including the discovery of its physiological/pathogenic mechanisms, and provides a reference for the feasible evaluation of AGK as a therapeutic target for human diseases, particularly tumors.
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作者：
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DOI：
10.1083/jcb.200407123
发表时间：
2005-06-06
期刊：
The Journal of cell biology
影响因子：
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作者：
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DOI：
10.3233/trd-180020
发表时间：
2018-04-13
期刊：
Translational science of rare diseases
影响因子：
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通讯作者：
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