Modulatory effects of adenosine on baroreflex activation in the brainstem of normotensive rats.
Modulatory effects of adenosine on baroreflex activation in the brainstem of normotensive rats.
复制标题
腺苷对正常血压大鼠脑干压力反射激活的调节作用。
DOI：
10.1016/0014-2999(89)90882-0
复制
发表时间：
1989
影响因子：
5
通讯作者：
Robertson,D
中科院分区：
文献类型：
--
作者：
Mosqueda-Garcia,R;Tseng,CJ;Appalsamy,M;Robertson,D
腺苷拮抗剂1,3-二丙基-8-对巯基黄嘌呤（DPSPX）和咖啡因对正常血压的Sprague-Dawley大鼠的压力反射活性的影响进行了研究。将DPSPX （0.92 nmol）微量注射到脲烷麻醉动物的孤束核（NTS）中，对基础血压和心率没有影响，但对苯肾上腺素引起的反射性心动过缓有抑制作用。在清醒或麻醉的动物脑内给予咖啡因后，观察到类似的对压力反射激活的抑制作用。这些结果表明，中枢内源性腺苷参与了髓质对血压的调节，腺苷拮抗剂如咖啡因可以抑制压力反射的激活。
The effects of the adenosine antagonists, 1,3-dipropyl-8-p-sulphenylxanthine (DPSPX) and caffeine, on baroreflex activity were tested in normotensive Sprague-Dawley rats. The microinjection of DPSPX (0.92 nmol) into the nucleus tractus solitarii (NTS) of urethane-anesthetized animals did not modify basal blood pressure or heart rate but inhibited the reflex bradycardia elicited by phenylephrine. Similar inhibitory effects on baroreflex activation were observed after intracisternal adminisration of caffeine to conscious or anesthetized animals. These results suggest that central endogenous adenosine is involved in the medullary regulation of blood pressure and that adenosine antagonists such as caffeine can inhibit baroreflex activation.