Acute dystonia during fixed-dose neuroleptic treatment.
Acute dystonia during fixed-dose neuroleptic treatment.
复制标题
固定剂量抗精神病药物治疗期间出现急性肌张力障碍。
DOI：
10.1097/00004714-199010060-00002
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发表时间：
1990
影响因子：
2.9
通讯作者：
Friedman,E
中科院分区：
文献类型：
--
作者：
Singh,H;Levinson,DF;Simpson,GM;Lo,ES;Friedman,E
：在随机、双盲研究中，86 名患有急性精神病加重的患者接受了口服氟奋乃静 10-30 毫克/天的固定剂量方案的治疗。 33.8% 的高危受试者发生肌张力障碍反应。其中，58% 发生在治疗第三天，88% 发生在第四天，100% 发生在治疗第九天；大多数发生在服药间隔后期。肌张力障碍反应的重要预测因素是氟奋乃静 mg/kg 剂量较高和年龄较小。接受异戊巴比妥钠治疗躁动的患者存在肌张力障碍风险较低的趋势。讨论了与抗精神病药引起的肌张力障碍的可能机制有关的结果。
: Eighty-six patients with acute psychotic exacerbations were treated with fixed dosage regimens of oral fluphenazine up to 10-30 mg/day in randomized, double-blind studies. Dystonic reactions occurred in 33.8% of the subjects at risk. Of these, 58% occurred by the third day, 88% by the fourth day, and 100% by the ninth day of treatment; most occurred later in the interdose interval. Significant predictors of dystonic reactions were higher fluphenazine mg/kg dosage and younger age. There was a trend toward a lower risk of dystonia in patients who received amobarbital sodium for agitation. Results are discussed in relation to possible mechanisms of neuroleptic-induced dystonia.