Interleukin-6 is increased in breath condensate of patients with non-small cell lung cancer
Interleukin-6 is increased in breath condensate of patients with non-small cell lung cancer
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DOI：
10.1177/172460080201700211
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发表时间：
2002-04-01
影响因子：
2
通讯作者：
Carpagnano, F
中科院分区：
文献类型：
--
作者：
Carpagnano, GE;Resta, O;Carpagnano, F
尽管近年来非小细胞肺癌（NSCLC）的诊断和治疗取得了进展，但大多数患者在诊断时仍表现为晚期疾病。最近的研究表明，IL-6参与了肺癌的发展。本研究的目的是探讨NSCLC患者呼吸凝析液中IL-6水平的测定是否可以用于提前诊断和监测疾病的进展。20例有组织学证据的非小细胞肺癌患者（14男6女，年龄638岁）和15例健康对照（8男7女，年龄456岁）纳入研究。采用特异性酶免疫测定试剂盒测定患者和对照组呼出液中il - 6的含量。非小细胞肺癌患者呼出的il - 6浓度（9.6+/-0.3 pg/mL）高于对照组（3.5+/-0.2 pg/mL）。不同分期NSCLC患者之间的差异具有统计学意义：转移性疾病患者的IL-6浓度（10.9+/-0.5 pg/mL）高于III期（9.7+/-0.4 pg/mL）、II期（8.9+/-0.3 pg/mL）和I期（7.9+/-0.3 pg/mL）。这些结果提示，可以将NSCLC患者呼出液中IL-6的测量作为早期诊断和疾病监测的一个参数。
Despite recent advances in the diagnosis and treatment of non-small cell lung cancer (NSCLC), most patients still present with advanced stage disease at the time of diagnosis. Recent studies suggest that IL-6 is involved in the development of lung cancer. The aim of the present study was to investigate whether the measurement of IL-6 levels in the breath condensate of NSCLC patients could be used to bring forward the moment of diagnosis and to monitor the progression of the disease. Twenty patients with histological evidence of NSCLC (14 men and 6 women, age 63 8 years) and 15 healthy controls (8 men and 7 women, age 45 6 years) were enrolled in the study. IL6 was measured in the exhaled breath condensate of patients and controls by means of a specific enzyme immunoassay kit. Higher concentrations of exhaled IL6 were found in NSCLC patients (9.6+/-0.3 pg/mL) than in controls (3.5+/-0.2 pg/mL). A statistically significant difference was observed between patients with NSCLC at different stages: higher concentrations of IL-6 (10.9+/-0.5 pg/mL) were found in patients with metastatic disease than in those with stage III (9.7+/-0.4 pg/mL), stage II (8.9+/-0.3 pg/mL) and stage I disease (7.9+/-0.3 pg/mL). These findings suggest that the measurement of IL-6 in the breath condensate of patients with NSCLC could be proposed as a parameter to take into account in early diagnosis and disease monitoring.