Optimized hydrophobically modified chitosan cryogels for strength and drug delivery systems
Optimized hydrophobically modified chitosan cryogels for strength and drug delivery systems
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DOI：
10.1016/j.jbiosc.2021.03.008
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发表时间：
2021-06-16
影响因子：
2.8
通讯作者：
Takei, Takayuki
中科院分区：
文献类型：
--
作者：
Evans, Courtney;Morimitsu, Yuto;Takei, Takayuki
本研究成功地制备了疏水改性壳聚糖冻凝胶。采用还原胺化法对壳聚糖进行烷基化改性。通过改变烷基链的长度和取代度，可以优化所得到的冷冻凝胶的强度，以及疏水染料的吸附和释放，疏水药物的模型。通过优化这些属性，发现水凝胶具有作为生物医学材料的潜力。(C)2021年，生物技术学会，日本。All rights reserved.
This research reports the success of the fabrication of hydrophobically modified chitosan cryogel. Chitosan was modified with alkyl groups through reductive animation. By varying the alkyl chain length and the substitution degree, the resulting cryogel could be optimized for strength, and the adsorption and release of hydrophobic dye, a model for hydrophobic medicines. By optimizing these attributes, the hydrogel was found to have the potential as a biomedical material. (C) 2021, The Society for Biotechnology, Japan. All rights reserved.