Inflammation, complement activation and endothelial function in stable and unstable coronary artery disease
Inflammation, complement activation and endothelial function in stable and unstable coronary artery disease
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DOI：
10.1016/j.cca.2005.08.028
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发表时间：
2006-03-01
影响因子：
5
通讯作者：
Marwick, TH
中科院分区：
文献类型：
--
作者：
Kostner, KM;Fahti, RB;Marwick, TH
背景：内皮功能障碍在冠状动脉疾病（CAD）的发病机制中起重要作用。除了传统的危险因素，补体激活和炎症可能引发和维持内皮功能障碍。我们试图评估内皮功能，高敏C-反应蛋白（hs-CRP）和补体激活的标志物在稳定或不稳定的冠状动脉diseases.Methods患者之间的关联：我们前瞻性招募了78例患者，35例稳定型心绞痛（SAP）和43例不稳定型心绞痛（UAP）。以肱动脉反应性（BAR）评估内皮功能。Hs-CRP、C3a、C5a和C1抑制剂（C1 inh.）结果：与SAP患者相比，IJAP患者hs-CRP和C3a的中位数水平较高，而BAR在患者组间无显著差异。在不稳定型心绞痛患者中，hs-CRP与胆固醇（r = 0.27，p <0.02）、C3a（r = 0.32，p <0.001）和C1INH显著相关。（r = 0.41，p <0.003），但不与流量介导的扩张（r = 0.09，P = 0.41）。Hs-CRP和C1 INH被发现是独立的预测因子IJAP在一个向后逐步Logistic回归model.Conclusions：我们得出结论，无论是hs-CRP，炎症标志物和C3a，补体激活的标志物是升高的不稳定型心绞痛患者，但不是在SAP患者。(c)2005 Elsevier B.V.保留所有权利。
Background: Endothelial dysfunction plays an important role in the pathogenesis of coronary artery disease (CAD). Apart from traditional risk factors complement activation and inflammation may trigger and sustain endothelial dysfunction. We sought to assess the association between endothelial function, high sensitivity C-reactive protein (hs-CRP) and markers of complement activation in patients with either stable or unstable coronary artery disease.Methods: We prospectively recruited 78 patients, 35 patients with stable angina pectoris (SAP) and 43 patients with unstable angina pectoris (UAP). Endothelial function was assessed as brachial artery reactivity (BAR). Hs-CRP, C3a, C5a, and C1-Inhibitor (C1 inh.) were measured enzymatically.Results: Patients with IJAP showed higher median levels of hs-CRP and C3a compared to patients with SAP, while BAR was not significantly different between patient groups. In UAP patients, hs-CRP was significantly correlated with cholesterol (r = 0.27, p < 0.02), C3a (r = 0.32, p < 0.001) and C1 INH.(r = 0.41, p < 0.003), but not with flow mediated dilatation (r = 0.09, P = 0.41). Hs-CRP and C1 INH.were found to be independant predictors of IJAP in a backward stepwise logistic regression model.Conclusions: We conclude that both hs-CRP, a marker of inflammation and C3a, a marker of complement activation are elevated in patients with UAP, but not in patients with SAP. (c) 2005 Elsevier B.V. All rights reserved.