Organozinc reagents in DMSO solvent:: Remarkable promotion of SN2′ reaction for allene synthesis
Organozinc reagents in DMSO solvent:: Remarkable promotion of SN2′ reaction for allene synthesis
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DOI：
10.1021/ol801249w
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发表时间：
2008-08-07
期刊：
影响因子：
5.2
通讯作者：
Kondo, Yoshinori
中科院分区：
文献类型：
--
作者：
Kobayashi, Koji;Naka, Hiroshi;Kondo, Yoshinori
在DMSO溶剂中，有机锌试剂与甲磺酸丙酯的S（N）2'反应得到了显著的改善，并且在不损失光学纯度的情况下，成功地实现了手性底物的立体选择性转化.
The S(N)2' reaction of propragyl mesylates with organozinc reagents was dramatically improved in DMSO solvent, and the stereoselective conversion of chiral substrates was successfully achieved using LiCl-free diorganozinc without the loss of optical purity.