Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America.
Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America.
复制标题
南美洲麻风分枝杆菌菌株的分子药物敏感性测试和基因分型。
DOI：
10.1128/aac.00201-11
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发表时间：
2011
影响因子：
4.9
通讯作者：
Cole,StewartT
中科院分区：
文献类型：
--
作者：
Singh,Pushpendra;Busso,Philippe;Paniz-Mondolfi,Alberto;Aranzazu,Nacarid;Monot,Marc;Honore,Nadine;deFariaFernandesBelone,Andrea;Virmond,Marcos;Villarreal-Olaya,MariaEsther;Rivas,Carlos;Cole,StewartT
用分子生物学方法对委内瑞拉和其他三个南美国家麻风分枝杆菌菌株可能的耐药性进行了调查。230例麻风新病例中没有一个菌株表现出耐药相关突变。然而，复发病例的三个菌株中有两个含有氨苯砜耐药突变，一个菌株还含有利福平耐药突变。单核苷酸多态性分析显示5种亚型：3I（73.8%）、4P（11.6%）、1D（6.9%）、4N（6%）和4O（1.7%）。
Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).