Raised plasma oxidised LDL in acute cerebral infarction
Raised plasma oxidised LDL in acute cerebral infarction
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DOI：
10.1136/jnnp.74.3.312
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发表时间：
2003-03-01
影响因子：
11
通讯作者：
Nagahiro, S
中科院分区：
文献类型：
--
作者：
Uno, M;Kitazato, KT;Nagahiro, S
背景：氧化低密度脂蛋白（OADL）和脑梗死之间的关系被怀疑但尚未确定。目的：为了确定血浆氧化低密度脂蛋白是否是一个有用的标志物监测氧化应激在中风patients.Methods：血浆氧化低密度脂蛋白浓度测定56例脑梗死（n = 45）或脑出血（n = 11），并在19个年龄匹配的对照组，使用一种新的夹心酶联免疫吸附试验。与对照组（0.130（0.007）ng/mug LDL，平均值（SEM））相比，脑梗死患者的OxLDL显著升高（0.245（0.022）; p < 0.0001），但出血患者的OxLDL没有显著升高（0.179（0.023））。皮质缺血性梗死患者（n = 22）的OxLDL水平高于对照组（p < 0.0001）或非皮质缺血性梗死患者（n = 23）（p < 0.001）。皮质梗死患者的OxLDL浓度增加持续到卒中发作后第三天。皮质性脑梗死患者的美国国立卫生研究院卒中量表评分高于非皮质性脑梗死患者（P < 0.01）。结论：血浆OxLDL升高与急性脑梗死，尤其是皮质性脑梗死有显著相关性。血浆OADL水平可反映脑卒中患者的氧化应激状态。
Background: The association between oxidised low density lipoprotein (OADL) and cerebral infarction is suspected but not established. Objectives: To determine whether plasma OxLDL is a useful marker for monitoring oxidative stress in stroke patients.Methods: Plasma OxLDL concentrations were determined in 56 stroke patients with cerebral infarction (n = 45) or cerebral haemorrhage (n = 11), and in 19 age matched controls, using a novel sandwich enzyme linked immunosorbent assay.Results: Compared with the controls (0.130 (0.007) ng/mug LDL, mean (SEM)), OxLDL was significantly raised in patients with cerebral infarction (0.245 (0.022); p < 0.0001) but not in those with haemorrhage (0.179 (0.023)). Patients with cortical ischaemic infarcts (n = 22) had higher OxLDL levels than either the controls (p < 0.0001) or the patients with non-cortical ischaemic infarcts (n = 23) (p < 0.001). Increased OxLDL concentrations in patients with cortical infarcts persisted until the third day after stroke onset. The National Institutes of Health stroke scales in patients with cortical infarction were higher than in those with non-cortical infarction (p < 0.01).Conclusions: There is a significant association between raised plasma OxLDL and acute cerebral infarction, especially cortical infarction. Plasma OADL may reflect oxidative stress in stroke patients.