Neuropsychological deficits among patients with late-onset minor and major depression
Neuropsychological deficits among patients with late-onset minor and major depression
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DOI：
10.1016/s0887-6177(03)00022-2
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发表时间：
2003-07-01
影响因子：
2.6
通讯作者：
Gur, RE
中科院分区：
文献类型：
--
作者：
Elderkin-Thompson, V;Kumar, A;Gur, RE
对轻度抑郁症患者（N = 28）、重度抑郁症患者（N = 26）和健康老年人（N = 38）的认知能力进行横断面检查，以确定迟发性抑郁症患者的认知能力是否随疾病严重程度的增加而降低，以及轻度抑郁症患者的认知评分是否介于健康老年人和重度抑郁症患者之间。认知测试分数的汇总组内主成分分析确定了五个组成部分，其中三个显示出显着的组间差异。言语回忆和维持集分离控制从重大抑郁症患者和轻微的从重大抑郁症患者。执行功能将控制组与轻度抑郁症患者分开，工作记忆是将控制组与重度抑郁症患者分开的边界。代表非语言识别的成分没有统计学意义。控制年龄和教育程度的偏相关表明，认知能力确实会随着抑郁症严重程度的增加而降低，并且这种变化的幅度从一种趋势到一种显着的赤字，取决于认知领域。这种认知能力的下降与神经解剖学研究中观察到的类似趋势相似，即额叶和颞叶的体积随着抑郁症严重程度的增加而减少。(C)2003年美国国家神经心理学学会。由爱思唯尔科技有限公司出版。保留所有权利。
Cognitive ability of minor depressed patients (N = 28), major depressed patients (N = 26) and healthy elderly (N = 38) was examined cross-sectionally to determine if cognitive abilities of patients with late-onset depression decrease with increasing severity of disease and if cognitive scores for minor depressed patients fall between those of healthy elderly and major depressed patients. A pooled within-group principal component analysis of cognitive test scores identified five components, three of which showed significant group differences. Verbal Recall and Maintenance of Set separated controls from major depressed patients and minor from major depressed patients. Executive Functioning separated controls from minor depressed patients, and Working Memory was borderline for separating controls from major depressed patients. The component representing Nonverbal Recognition was not statistically significant. Partial correlations controlling for age and education indicate that cognitive performance does decrease as severity of depression increases, and the magnitude of the change varies from a trend to a significant deficit depending on the cognitive domain. This decline in cognitive performance parallels a similar trend observed in neuroanatomical studies in which the volume of the frontal and temporal lobes decrease with increasing severity of depression. (C) 2003 National Academy of Neuropsychology. Published by Elsevier Science Ltd. All rights reserved.