Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer.
Therapeutic Potential of Pigment Epithelium-derived Factor in Cancer.
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DOI：
10.2174/1381612825666190319112106
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发表时间：
2019
影响因子：
3.1
通讯作者：
S. Yamagishi;Yoshinori Koga;Ami Sotokawauchi;N. Hashizume;S. Fukahori;T. Matsui;M. Yagi
中科院分区：
文献类型：
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作者：
S. Yamagishi;Yoshinori Koga;Ami Sotokawauchi;N. Hashizume;S. Fukahori;T. Matsui;M. Yagi
色素上皮衍生因子（PEDF）是一种具有多功能特性的丝氨酸蛋白酶抑制剂，由多种器官和组织产生。越来越多的证据表明 PEDF 在维持组织稳态中发挥着重要作用。事实上，PEDF 不仅可以作为血管生成的内源性抑制剂，还可以抑制细胞培养系统、动物模型和人类中的氧化应激、炎症和血栓反应。此外，我们和其他人一起发现 PEDF 抑制多种肿瘤的增殖并诱导细胞凋亡。此外，PEDF 的循环以及肿瘤表达水平与肿瘤生长和转移呈负相关。这些观察结果表明，补充 PEDF 蛋白和/或增强内源性 PEDF 表达可能是治疗癌症的新治疗策略。因此，在本文中，我们回顾了PEDF对不同类型癌症的影响，并讨论了其治疗前景。
Pigment epithelium-derived factor (PEDF) is one of the serine protease inhibitors with multifunctional properties, which is produced by various types of organs and tissues. There is an accumulating body of evidence that PEDF plays an important role in the maintenance of tissue homeostasis. Indeed, PEDF not only works as an endogenous inhibitor of angiogenesis, but also suppresses oxidative stress, inflammatory and thrombotic reactions in cell culture systems, animal models, and humans. Furthermore, we, along with others, have found that PEDF inhibits proliferation of, and induces apoptotic cell death in, numerous kinds of tumors. In addition, circulating as well as tumor expression levels of PEDF have been inversely associated with tumor growth and metastasis. These observations suggest that supplementation of PEDF proteins and/or enhancement of endogenous PEDF expression could be a novel therapeutic strategy for the treatment of cancer. Therefore, in this paper, we review the effects of PEDF on diverse types of cancer, and discuss its therapeutic perspectives.