CACNA1C risk variant affects microstructural connectivity of the amygdala
CACNA1C risk variant affects microstructural connectivity of the amygdala
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DOI：
10.1016/j.nicl.2019.101774
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发表时间：
2019-03
期刊：
影响因子：
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通讯作者：
K. Koch;Sophia Stegmaier;Lena Schwarz;M. Erb;Mara Thomas;K. Scheffler;D. Wildgruber;V. Nieratschker;T. Ethofer
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文献类型：
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作者：
K. Koch;Sophia Stegmaier;Lena Schwarz;M. Erb;Mara Thomas;K. Scheffler;D. Wildgruber;V. Nieratschker;T. Ethofer
情感障碍患者在行为和神经水平上存在情绪韵律感知缺陷。在目前的研究中，我们使用成像遗传学的方法来检查的影响ofCACNA1C，最有前途的遗传风险因素之一的精神疾病，韵律加工的行为，功能和微观结构水平。使用功能性磁共振成像（fMRI）和扩散张量成像（DTI），我们检查了参与韵律处理的关键区域，即杏仁核和语音区，在健康人群中。我们发现在语音区和杏仁核中，情绪韵律比中性韵律激活更强，但CACNA1Crs1006737基因型对fMRI活性没有影响。然而，显着的微结构差异（即平均扩散率）betweenCACNA1Crs1006737危险等位基因携带者和非携带者被发现在杏仁核，但不是声音区。这些与CACNA1C相关的大脑结构的改变可能反映了一种易患情感障碍的神经生物学标记，以及伴随的情感感知的改变。
Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact ofCACNA1C, one of the most promising genetic risk factors for psychiatric disorders, on prosody processing on a behavioral, functional and microstructural level. Using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) we examined key areas involved in prosody processing, i.e. the amygdala and voice areas, in a healthy population. We found stronger activation to emotional than neutral prosody in the voice areas and the amygdala, butCACNA1Crs1006737 genotype had no influence on fMRI activity. However, significant microstructural differences (i.e. mean diffusivity) betweenCACNA1Crs1006737 risk allele carriers and non carriers were found in the amygdala, but not the voice areas. These modifications in brain architecture associated withCACNA1Cmight reflect a neurobiological marker predisposing to affective disorders and concomitant alterations in emotion perception.