The presence of PCDDs and PCDFs in human breast milk from the Netherlands
The presence of PCDDs and PCDFs in human breast milk from the Netherlands
复制标题
荷兰母乳中存在 PCDD 和 PCDF
DOI：
10.1016/0045-6535(86)90035-4
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发表时间：
1986
期刊：
影响因子：
8.8
通讯作者：
C. Boxtel
中科院分区：
文献类型：
--
作者：
M. Berg;F. W. M. Wielen;K. Olie;C. Boxtel
Sixteen individual and two pooled human milk samples were analyzed for PCDDs and PCDFs. All detected PCDD and PCDF congeners had a 2,3,7,8-chlorine substitution pattern.The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2 – 2.6 ppt), 1,2,3,6,7,8-HxCDD (0.2 – 5.7 ppt), 1,2,3,4,6,7,8-HpCDD (1.3 – 19.1) and OCDD (1.7 – 37.8 ppt), with concentrations on total milk basis.Minor components were 1,2,3,7,8-PnCDD, 1,2,3,7,8,9- and 1,2,3,4,7,8- HxCDD (⩽ 1 ppt). Qualitatively and quantitatively the milk samples from the Netherlands strongly resemble those from Sweden and West-Germany. A linear relationship was found between some congeners. This correlation was highest for congeners having an equal number of chlorine atoms or those with a difference of one chlorine atom.By using a one compartment open model for multiple doses, a maximum liver concentration of approximately 200 ppt 2,3,4,7,8-PnCDF in the neonate was calculated after six months.
