Intrinsic axonal degeneration pathways are critical for glaucomatous damage.
Intrinsic axonal degeneration pathways are critical for glaucomatous damage.
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DOI：
10.1016/j.expneurol.2012.01.014
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发表时间：
2013-08
影响因子：
5.3
通讯作者：
John, Simon W. M.
中科院分区：
文献类型：
--
作者：
Howell, Gareth R.;Soto, Ileana;Libby, Richard T.;John, Simon W. M.
Glaucoma is a neurodegenerative disease affecting 70 million people worldwide. For some time, analysis of human glaucoma and animal models suggested that RGC axonal injury in the optic nerve head (where RGC axons exit the eye) is an important early event in glaucomatous neurodegeneration. During the last decade advances in molecular biology and genome manipulation have allowed this hypothesis to be tested more critically, at least in animal models. Data indicate that RGC axon degeneration precedes soma death. Preventing soma death using mouse models that are mutant for BAX, a proapoptotic gene, is not sufficient to prevent the degeneration of RGC axons. This indicates that different degeneration processes occur in different compartments of the RGC during glaucoma. Furthermore, the Wallerian degeneration slow allele (Wlds) slows or prevents RGC axon degeneration in rodent models of glaucoma. These experiments and many others, now strongly support the hypothesis that axon degeneration is a critical pathological event in glaucomatous neurodegeneration. However, the events that lead from a glaucomatous insult (e.g. elevated intraocular pressure) to axon damage in glaucoma are not well defined. For developing new therapies, it will be necessary to clearly define and order the molecular events that lead from glaucomatous insults to axon degeneration.
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影响因子：
5.1
作者：
Anderson, DR
通讯作者：
Anderson, DR
影响因子：
7.8
作者：
Cavalli, V;Kujala, P;Goldstein, LSB
通讯作者：
Goldstein, LSB
影响因子：
3.4
作者：
Adalbert, R;Gillingwater, TH;Coleman, MP
通讯作者：
Coleman, MP
DOI：
10.1523/jneurosci.4065-10.2011
发表时间：
2011-01-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos SA;Martinez NW;Yoo S;Jara JS;Zamorano S;Hetz C;Twiss JL;Alvarez J;Court FA
通讯作者：
Court FA
影响因子：
4.4
作者：
Howell GR;Walton DO;King BL;Libby RT;John SW
通讯作者：
John SW