Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis.
Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis.
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DOI：
10.1177/2167702614534210
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Heller W
中科院分区：
文献类型：
--
作者：
Snyder HR;Kaiser RH;Warren SL;Heller W
强迫症（OCD）是一种严重的慢性致残疾病。目前强迫症的主流模型集中在支持执行功能（EF）的前额叶纹状体回路的异常。虽然有越来越多的证据表明EF障碍与强迫症有关，但结果并不一致，这使得这些障碍的性质和程度存在争议。目前的荟萃分析使用随机效应模型综合了110项先前的研究，这些研究比较了强迫症参与者和健康对照组参与者在至少一项EF神经心理学测量上的表现。结果表明，强迫症患者在测量EF的大多数方面的任务上受损，这与EF的广泛损害是一致的。EF缺陷不能用一般的运动迟缓或抑郁来解释。尽管药物使用、年龄和性别缓和了一些影响，但在人口统计学和临床特征样本的变化中，效应量基本稳定。
Obsessive-compulsive disorder (OCD) is a serious and often chronically disabling condition. The current dominant model of OCD focuses on abnormalities in prefrontal-striatal circuits that support executive function (EF). While there is growing evidence for EF impairments associated with OCD, results have been inconsistent, making the nature and magnitude of these impairments controversial. The current meta-analysis uses random-effects models to synthesize 110 previous studies that compared participants with OCD to healthy control participants on at least one neuropsychological measure of EF. The results indicate that individuals with OCD are impaired on tasks measuring most aspects of EF, consistent with broad impairment in EF. EF deficits were not explained by general motor slowness or depression. Effect sizes were largely stable across variation in demographic and clinical characteristics of samples, although medication use, age, and gender moderated some effects.