Metabolic control of dendritic cell activation and function: recent advances and clinical implications.
Metabolic control of dendritic cell activation and function: recent advances and clinical implications.
复制标题
树突状细胞激活和功能的代谢控制：最新进展和临床意义。
DOI：
10.3389/fimmu.2014.00203
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发表时间：
2014
影响因子：
7.3
通讯作者：
Pearce EJ
中科院分区：
文献类型：
--
作者：
Everts B;Pearce EJ
树突状细胞（Dendritic cells，DC）是免疫和耐受的关键调节因子，通过控制效应性T辅助细胞和调节性T细胞的活化和极化而发挥作用。因此，主要关注开发用于免疫治疗的操纵DC功能的方法。众所周知，细胞活化的变化与细胞代谢的深刻变化相关联。在过去的十年中，人们越来越认识到这些代谢变化也是免疫细胞执行特定功能的能力的基础。这导致了这样的概念，即细胞代谢的操纵可用于形成先天性和适应性免疫反应。虽然我们在这一领域的大部分理解都是从T细胞和巨噬细胞的研究中获得的，但有证据表明，DC的激活和功能也取决于这些细胞参与的代谢类型。我们在这里讨论这些新的见解，并探讨是否靶向的代谢途径在DC可能持有承诺作为一种新的方法来操纵DC的功能特性用于临床目的。
Dendritic cells (DCs) are key regulators of both immunity and tolerance by controlling activation and polarization of effector T helper cell and regulatory T cell responses. Therefore, there is a major focus on developing approaches to manipulate DC function for immunotherapy. It is well known that changes in cellular activation are coupled to profound changes in cellular metabolism. Over the past decade there is a growing appreciation that these metabolic changes also underlie the capacity of immune cells to perform particular functions. This has led to the concept that the manipulation of cellular metabolism can be used to shape innate and adaptive immune responses. While most of our understanding in this area has been gained from studies with T cells and macrophages, evidence is emerging that the activation and function of DCs are also dictated by the type of metabolism these cells commit to. We here discuss these new insights and explore whether targeting of metabolic pathways in DCs could hold promise as a novel approach to manipulate the functional properties of DCs for clinical purposes.
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影响因子：
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通讯作者：
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