Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma.
Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma.
复制标题
DOI：
10.3892/or.18.4.981
复制
发表时间：
2007-10
期刊：
影响因子：
4.2
通讯作者：
Yoichiro Mori;H. Ishiguro;Y. Kuwabara;M. Kimura;A. Mitsui;H. Kurehara;R. Mori;K. Tomoda;R. Ogawa
中科院分区：
文献类型：
--
作者：
Yoichiro Mori;H. Ishiguro;Y. Kuwabara;M. Kimura;A. Mitsui;H. Kurehara;R. Mori;K. Tomoda;R. Ogawa
本研究旨在检测食管癌相关基因4（ECRG 4）mRNA在食管鳞状细胞癌（ESCC）中的表达，并探讨其临床意义。采用实时荧光定量RT-PCR方法检测63例ESCC及相应正常食管黏膜组织中ECRG 4 mRNA的表达。ECRG 4 mRNA表达水平在ESCC组织中显著低于相应的正常食管粘膜（P<0.0001），在局部浸润性T2-4肿瘤患者中显著低于浸润性较低的T1肿瘤（P=0.0229），在4期肿瘤中显著低于0-3期肿瘤（P=0.0120）。此外，与ECRG 4 mRNA高表达水平相比，ECRG 4 mRNA低表达水平与ESCC患者术后生存期显著缩短相关（P=0.0150）。在多因素分析的基础上，我们得出结论，ECRG 4 mRNA表达水平可能是ESCC患者的独立预后因素的候选人。
In this study, we examined the expression of esophageal cancer-related gene 4 (ECRG4) mRNA and evaluated its clinical significance in esophageal squamous cell carcinoma (ESCC). ECRG4 mRNA expression was quantified by real-time RT-PCR in 63 ESCC and corresponding normal esophageal mucosal samples. ECRG4 mRNA expression levels were significantly lower in ESCC tissues compared with corresponding normal esophageal mucosa (P<0.0001), in patients with locally invasive T2-4 tumors compared with less invasive T1 tumors (P=0.0229) and in stage 4 tumors compared with stage 0-3 tumors (P=0.0120). Furthermore, low ECRG4 mRNA expression levels were associated with significantly shorter survival after surgery compared with high ECRG4 mRNA expression levels (P=0.0150) in ESCC patients. On the basis of multivariate analysis, we conclude that ECRG4 mRNA expression level could be a candidate for an independent prognostic factor for ESCC patients.