ANGIOGENESIS INDUCED BY NORMAL HUMAN-BREAST TISSUE - A PROBABLE MARKER FOR PRE-CANCER
ANGIOGENESIS INDUCED BY NORMAL HUMAN-BREAST TISSUE - A PROBABLE MARKER FOR PRE-CANCER
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DOI：
10.1126/science.6181563
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
LEWIS, AE
中科院分区：
文献类型：
--
作者：
JENSEN, HM;CHEN, I;LEWIS, AE
正常人乳腺小叶，新鲜分离的精确显微切割组织染色的亚甲蓝氯化物，测定其诱导新生血管形成（血管生成）的能力，在兔虹膜。从组织学上看，正常乳腺癌小叶诱导血管生成的频率是非癌乳腺小叶的两倍，这表明癌前转化是弥漫性的。
Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breasts induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.