Coexistence of chronic myeloid leukemia and hairy cell leukemia of common clonal origin
Coexistence of chronic myeloid leukemia and hairy cell leukemia of common clonal origin
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DOI：
10.1016/s0165-4608(01)00632-x
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发表时间：
2002-04-15
影响因子：
--
通讯作者：
Radványi, G
中科院分区：
文献类型：
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作者：
Pajor, L;Kereskai, L;Radványi, G
一个40岁的病人的历史是谁被承认与慢性粒细胞白血病（CML）的临床图片。化验结果。骨髓形态学和分子学研究支持这一诊断，包括支持费城染色体阳性慢性骨髓增生的b3/a2以及b2/a2嵌合mRNA表达。但只占骨髓的一小部分。可以看到与CML不同的浸润。此外，形态学、细胞化学。免疫表型和分子生物学分析表明，共存的肿瘤是毛细胞白血病（HCL）。细胞谱系特异性间期细胞遗传学分析证明了两种肿瘤之间的克隆关系，即HCL来自其中一种B细胞。基于两个细胞遗传学标记属于最初的CML克隆体(C)2002年爱思唯尔科技有限公司All rights reserved.
The history of a forty year old patient is presented who was admitted with a clinical picture of chronic myeloid leukemia (CML). Laboratory findings. bone marrow morphology and molecular investigations supported this diagnosis, including b3/a2 as well as b2/a2 chimeric mRNA expression in support of a Philadelphia chromosome positive chronic myeloproliferation. In a fraction of the bone marrow content, however. an infiltrate different from that of CML could be seen. In addition, the morphology, cytochemistry. immunophenotyping and molecular analysis indicated that the coexisting neoplasia is hairy cell leukemia (HCL). Cell lineage specific interphase cytogenetic analysis proved a clonal relationship between the two neoplasias in a way that the HCL arose from one of the B-cells which. based on two cytogenetic markers. belonged to the original CML clone. (C) 2002 Elsevier Science Inc. All rights reserved.