Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI
Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI
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DOI：
10.1007/s10334-016-0590-z
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发表时间：
2017-04-01
影响因子：
2.3
通讯作者：
Hu, Xiaoping
中科院分区：
文献类型：
--
作者：
Langley, Jason;Huddleston, Daniel E.;Hu, Xiaoping
本研究的目的是评估神经黑素敏感MRI对黑质和蓝斑的描绘和测量的重复性。每次扫描提取SNpc和LC体积。使用组内相关系数（ICC）和骰子相似系数（DSC）评估SNpc和LC中体积和磁化传递对比测量的再现性。SNpc和LC体积测量显示出良好的再现性（SNpc-ICC：0.94，p < 0.001; LC-ICC：0.96，p < 0.001）。SNpc和LC在扫描之间被准确地描绘（SNpc-DSC：0.80 +/- 0.03; LC-DSC：0.63 +/- 0.07）。神经黑素敏感的MRI可以一致地描绘SNpc和LC。
The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI.Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC).SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 +/- 0.03; LC-DSC: 0.63 +/- 0.07).Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.