The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
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DOI：
10.1099/00221287-146-8-1797
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发表时间：
2000-08-01
期刊：
影响因子：
2.8
通讯作者：
Saier, MH
中科院分区：
文献类型：
--
作者：
Jack, DL;Paulsen, IT;Saier, MH
在本文中，175个目前测序的转运蛋白，包括氨基酸/多胺/有机定位（APC）超家族的分析报告。该超家族的成员分为10个明确定义的家族，这些家族要么是原核生物特异性的，要么是真核生物特异性的或普遍存在的。这些蛋白质中的大多数表现出12个可能的跨膜蛋白（TMS），但这些家族中的两个成员偏离这种模式，表现出10和14 TMS。这些家庭的所有成员列表，他们的功能特性进行审查和系统发育/序列分析定义的蛋白质彼此的进化关系。有证据表明，APC超家族可能包括其他两个目前公认的家庭，表现出更大程度的序列差异，从APC超家族成员比10个已建立的家庭的蛋白质从彼此。这两个远亲家族的蛋白质成员中至少有一些表现出11个已建立的TMS。总的来说，APC超家族可能包括12个目前公认的家族，其成员对氨基酸及其衍生物表现出排他的特异性，但每条多肽链可以具有10、11、12或14个TMS。
In this paper an analysis of 175 currently sequenced transport proteins that comprise the amino acid/polyamine/organocation (APC) superfamily is reported. Members of this superfamily fall into 10 well-defined families that are either prokaryote specific, eukaryote specific or ubiquitous. Most of these proteins exhibit 12 probable transmembrane spanners (TMSs), but members of two of these families deviate from this pattern, exhibiting 10 and 14 TMSs. All members of these families are tabulated, their functional properties are reviewed and phylogenetic/sequence analyses define the evolutionary relationships of the proteins to each other. Evidence is presented that the APC superfamily may include two other currently recognized families that exhibit greater degrees of sequence divergence from APC superfamily members than do the proteins of the 10 established families from each other. At least some of the protein members of these two distantly related families exhibit 11 established TMSs. Altogether, the APC superfamily probably includes 12 currently recognized families with members that exhibit exclusive specificity for amino acids and their derivatives but which can possess 10, 11, 12 or 14 TMSs per polypeptide chain.