A two-layer diffusive model for describing the variability of transdermal drug permeation
A two-layer diffusive model for describing the variability of transdermal drug permeation
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DOI：
10.1016/j.ejpb.2009.12.003
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发表时间：
2010-03-01
影响因子：
4.9
通讯作者：
Pritchard, David
中科院分区：
文献类型：
--
作者：
Meidan, Victor M.;Pritchard, David
越来越多的证据表明，描述任何给定的药物经皮渗透过程的渗透系数(k(P))通常服从某种形式的正偏、非对称分布，而不是简单的正态分布。然而，本文迄今尚未对这一区域进行适当的理论处理。我们描述了一个双层模型，它可以解释先前发表的两篇论文中测量的五种药物的k(P)在变量上的变化。该模型说明了为什么快速渗透的CHUG倾向于呈现微尘对称的k(P)分布，而逐渐缓慢渗透的药物倾向于呈现逐渐更正的k(P)分布。未来的研究在比较亲水性和亲脂性药物的通量变量时应该考虑这种影响(C)2009年Elsevier B.V.所有灯保留
There is mounting evidence that the permeability coefficients (k(p)) that describe any given transdermal drug permeation process generally follow some form of positively skewed, non-symmetrical distribution lather than a simple normal distribution Yet a suitable theoretical treatment of this area has not been undertaken to date In this paper, we describe a two-layer model that can explain five drugs' k(p) at variabilities as measured in two previously published papers The model shows why rapidly permeating chugs would tend to exhibit mote symmetrical k(p) distributions while progressively more slowly permeating drugs would tend to exhibit progressively more positively skewed k(p) distributions Future research should take this effect into account when comparing the flux variabilities of hydrophilic and lipophilic drugs (c) 2009 Elsevier B.V All lights reserved