Platelet glycoprotein Ia C807T, Ib C3550T, and IIIa P1A1/A2 polymorphisms and ischemic stroke in young Taiwanese
Platelet glycoprotein Ia C807T, Ib C3550T, and IIIa P1A1/A2 polymorphisms and ischemic stroke in young Taiwanese
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DOI：
10.1016/j.jns.2004.07.019
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发表时间：
2004-12-15
影响因子：
4.4
通讯作者：
Lai, ML
中科院分区：
文献类型：
--
作者：
Chen, CH;Lo, YK;Lai, ML
血小板在血栓性心血管疾病的发病机制中起关键作用。最近，血小板糖蛋白（GP）基因多态性被报道与缺血性卒中风险增加有关。摘要本研究旨在探讨台湾青少年血小板GP基因变异与缺血性脑卒中的关系。我们在2001年9月至2003年3月期间招募了157名年轻缺血性卒中患者和157名年龄和性别匹配的对照组进行了病例对照研究。采用聚合酶链反应-限制性片段长度多态性分析血小板GP la C807T、GP Ib C3550T和GP IIIa Pl（A1/A2）多态性的基因型。数据分析采用学生t检验、卡方检验和logistic回归模型。GP la C807T CC、CT和TT基因型频率在患者（50.3%、43.9%、5.7%）和对照组（53.5%、38.9%、7.6%,p=0.58）之间相似。GP Ib C3550T CC和CT基因型分布在患者（91.1%,8.9%）和对照组（91.7%,8.3%,p=0.84）之间无显著差异。所有受试者均未携带GP IIIa pl（A2）突变。综上所述，血小板GP la C807T和GP Ib C3550T多态性在我国人群中较白种人少见，GP IIIa pl（A1/A2）基因突变未发现，且均与台湾青年缺血性脑卒中无关。(C) 2004 Elsevier B.V.版权所有
Platelet plays a pivotal role in the pathogenesis of thrombotic cardiovascular diseases. Recently, the polymorphism of platelet glycoprotein (GP) genes has been reported to be associated with an increased risk for ischemic stroke. The purpose of this study is to evaluate the association between platelet GP genetic variants and ischemic stroke in young Taiwanese. We conducted a case-control study in 157 young ischemic stroke patients recruited between September 2001 and March 2003 and 157 age- and sex-matched controls. The genotypes of platelet GP la C807T, GP Ib C3550T, and GP IIIa Pl(A1/A2) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Student's t-test, chi-square test, and logistic regression modeling were used for data analyses. The GP la C807T CC, CT and TT genotype frequencies were similar between patients (50.3%, 43.9%, 5.7%) and controls (53.5%, 38.9%, 7.6%; p=0.58). There were no significant differences in GP Ib C3550T CC and CT genotype distributions between patients (91.1%, 8.9%) and controls (91.7%, 8.3%; p=0.84). Of all subjects, none carries GP IIIa pl(A2) mutation. In conclusion, platelet GP la C807T and GP Ib C3550T polymorphisms in our population are less common compared with Caucasians, and GP IIIa pl(A1/A2) genetic mutation is not found, and all of them are not associated with ischemic stroke in young Taiwanese. (C) 2004 Elsevier B.V. All rights reserved.